Tag Archives: long non-coding RNA

Call For Papers – Special Issue: Non-coding RNAs in Cancer

Editor: Aamir Ahmad, PhD, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA Deadline: October 15th, 2016 Cancer is a deadly disease that affects millions of lives worldwide. The fight against cancer relies heavily on the availability of robust biomarkers for diagnosis, therapy and prognosis. In recent years, non-coding RNAs have attracted a lot of attention for their role in human cancers. The ...

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Role of long non-coding RNA in tumor drug resistance

lncRNA

Chemotherapy has been extensively used in tumor treatment, including either systemic or local treatment. Miserably, in many kinds of cancers, chemotherapy is gradually insensitive. The mechanisms of tumor drug resistance have been widely explored, yet have not been fully characterized. With several studies in the development of drug resistance, recent works have highlighted the involvement of non-coding RNAs in tumor ...

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Understanding the Functions of Long Non-Coding RNAs through Their Higher-Order Structures

lncRNA

Although thousands of long non-coding RNAs (lncRNAs) have been discovered in eukaryotes, very few molecular mechanisms have been characterized due to an insufficient understanding of lncRNA structure. Therefore, investigations of lncRNA structure and subsequent elucidation of the regulatory mechanisms are urgently needed. However, since lncRNA are high molecular weight molecules, which makes their crystallization difficult, obtaining information about their structure ...

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Featured lncRNA – Smooth Muscle Enriched Long Non-Coding RNA (SMILR)

lncRNA

Using RNA-sequencing, researchers from the University of Glasgow identified >300 lncRNAs whose expression was altered in human saphenous vein (HSV) VSMCs following stimulation with IL1α and PDGF. They focused on a novel lncRNA (Ensembl: RP11-94A24.1) which they termed smooth muscle induced lncRNA enhances replication (SMILR). Following stimulation, SMILR expression was increased in both the nucleus and cytoplasm, and was detected ...

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Long noncoding RNAs in lung cancer – what we know in 2015

lncRNA

Lung cancer ranks as the first most common cancer and the first leading cause of cancer-related death in China and worldwide. Due to the difficulty in early diagnosis and the onset of cancer metastasis, the 5-year survival rate of lung cancer remains extremely low. Long noncoding RNAs (lncRNAs), which lacking protein-coding ability, have recently emerged as pivotal participants in biological ...

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Hidden gene could help control anxiety

lncRNA

A new study has found the mechanism used by a hidden gene to affect how the brain responds to stressful experiences, in a discovery that could eventually help control anxiety. University of Queensland scientists, together with colleagues at the University of California Irvine and the Garvan Institute of Medical Research, discovered that Gomafu, a gene recently associated with schizophrenia, causes ...

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Featured long non-coding RNA – meiRNA

lncRNA

Long non-coding RNAs (lncRNAs) play key roles in the formation of nuclear bodies. In the fission yeast Schizosaccharomyces pombe, a lncRNA species termed meiRNA forms a nuclear dot structure at its own genetic locus, the sme2 locus, with its protein-binding partner Mei2. This dot structure, called Mei2 dot, promotes the progression of meiosis by suppressing Mmi1, a crucial factor involved ...

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Featured long non-coding RNA – meiRNA

lncRNA

Long non-coding RNAs (lncRNAs) play key roles in the formation of nuclear bodies. In the fission yeast Schizosaccharomyces pombe, a lncRNA species termed meiRNA forms a nuclear dot structure at its own genetic locus, the sme2 locus, with its protein-binding partner Mei2. This dot structure, called Mei2 dot, promotes the progression of meiosis by suppressing Mmi1, a crucial factor involved ...

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The four dimensions of noncoding RNA conservation

Evolutionary conservation is widely used as an indicator of the functional significance of newly discovered genes. Although the simple search for homology at the nucleotide or amino acid sequence level has proven to be valuable for protein-coding genes, these criteria are too narrow to describe fully the selection process for long noncoding RNAs (lncRNAs). LncRNA conservation includes four dimensions: the ...

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RaNA Therapeutics Raises $20.7 Million to Harness the Potential of Long Non-coding RNA

CAMBRIDGE, Mass.–(BUSINESS WIRE)–RaNA Therapeutics, Inc. today announced it has completed a $20.7 million round of financing co-led by Atlas Venture, SR One, and Monsanto, with participation of Partners Innovation Fund. The company is developing a technology platform to enable selective activation of target genes and expression of therapeutic factors by targeting a type of regulatory RNA called long non-coding RNA. ...

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