Tag Archives: long non-coding RNA

Development of a novel prognostic signature of long non-coding RNAs in lung adenocarcinoma

lncRNA

Increasing evidence suggests that long non-coding RNAs (lncRNAs) may play a crucial role in many biological processes in a variety of cancers and serve as the basis for many clinical applications including prognostic biomarkers and potential therapeutic targets. Researchers from the Fudan University Shanghai Cancer Center set out to develop a prognostic lncRNA signature with RNA-seq data in lung adenocarcinomas. ...

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Perspectives of long non-coding RNAs in cancer

lncRNA

A recent advance in transcriptomics has spawned the ‘Decade of non-coding RNAs’ by potentiating the growing numbers of long non-coding RNA in cancer. LncRNA involvement in cancer denotes its significance beyond our perception as they participate in tumor suppression and promoting oncogenesis, which raises them as a mighty class of effectors or regulators. Aberrantly expressed lncRNAs interact with major protein ...

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Post-doc Position Available – Epigenetic Alteration of Long Non-coding RNA

lncRNA

Ref. : 201601691 Posting Title : Post-doctoral Fellow in Epigenetic Alteration of Long Non-coding RNA Department : Department of Medicine Closing Date : April 13, 2017 Applications are invited for appointment as Post-doctoral Fellow in Epigenetic Alteration of Long Non-coding RNA in the Department of Medicine, to commence as soon as possible for three years, with the possibility of renewal. ...

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Potential of Long Non-coding RNAs in Cancer Patients: From Bio-markers to Therapeutic Targets

lncRNA

Because of high specificity and easy detection in the tissues, serum, plasma, urine and saliva, interest in exploring the potential of long non-coding RNAs (lncRNAs) in cancer patients continues to increase. LncRNAs have shown potential as a bio-marker in the diagnosis and prognosis of bladder cancer, prostate cancer, gastric cancer, pancreatic cancer, breast cancer, and many other cancer types. Some ...

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Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion

lncRNA

Long non-coding RNAs (lncRNAs) play critical roles in tumor development and progression. This study was undertaken to examine the expression and biological functions of a novel lncRNA SBDSP1 in colorectal cancer (CRC). Researchers from the Fudan University Shanghai Cancer Center used Quantitative real-time PCR analysis to measure the expression of SBDSP1 in CRC tissues and cell lines. Knockdown of SBDSP1 ...

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SINEUP lncRNAs represent a new versatile tool to improve the production of secreted proteins in biomanufacturing processes

lncRNA

Mammalian cells are an indispensable tool for the production of recombinant proteins in contexts where function depends on post-translational modifications. Among them, Chinese Hamster Ovary (CHO) cells are the primary factories for the production of therapeutic proteins, including monoclonal antibodies (MAbs). To improve expression and stability, several methodologies have been adopted, including methods based on media formulation, selective pressure and ...

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A potential role of LncRNAs expression in cardiac cell proliferation

lncRNA

Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult life of human heart has not been evaluated. Researchers at Wenzhou Medical University used immunofiuorescent staining to determine the extent of cardiac cell proliferation. Human LncRNA microarrays were applied ...

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The long non-coding RNA 91H increases aggressive phenotype of breast cancer cells

Numerous genomic imprinting loci are regulated by long non-coding RNA (lncRNA). University of Lille researchers have previously identified a new lncRNA at the H19/IGF2 locus transcribed in H19 antisense orientation and named 91H. This RNA is conserved among mammals. In mice, 91H regulates positively IGF2 expression from a novel promoter. However, in human the function of 91H at the H19/IGF2 ...

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G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage

lncRNA

Long non-coding RNAs (lncRNAs) are an emerging class of transcripts that can modulate gene expression; however, their mechanisms of action remain poorly understood. Here, MIT researchers experimentally determine the secondary structure of Braveheart (Bvht) using chemical probing methods and show that this ∼590 nt transcript has a modular fold. Using CRISPR/Cas9-mediated editing of mouse embryonic stem cells, they find that ...

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Dysregulation of long non-coding RNA in breast cancer

lncRNA

Long non-coding RNAs (lncRNAs), which occupy nearly 98% of genome, have crucial roles in cancer development, including breast cancer. Breast cancer is a disease with high incidence. Despite of recent progress in understanding the molecular mechanisms and combined therapy strategies, the functions and mechanisms of lncRNAs in breast cancer remains unclear. Researchers from Zhejiang University review the currently basic knowledge ...

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