Tag Archives: long intergenic noncoding RNA

The novel long intergenic noncoding RNA UCC promotes colorectal cancer

lncRNA

The human genome contains thousands of long intergenic noncoding RNAs (lincRNAs). However, the functional roles of these transcripts and the mechanisms responsible for their deregulation in colorectal cancer (CRC) remain elusive. Researchers at Sun Yat-sen University found a novel lincRNA termed upregulated in CRC (UCC) was highly expressed in human CRC tissues and cell lines. UCC levels correlated with lymph node ...

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Long noncoding RNA (lincRNA), a new paradigm in gene expression control

lncRNA

Long intergenic non-coding RNAs (lincRNAs) are defined as RNA transcripts that are longer than 200 nucleotides. By definition, these RNAs must not have open reading frames that encode proteins. Many of these transcripts are encoded by RNA polymerase II, are spliced, and are poly-adenylated. This final fact indicates that there is a trove of information about lincRNAs in databases such ...

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Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

lncRNA

Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and its underlying etiology and genomic structure are heterogeneous. Here a team led by researchers at the RIKEN Center for Integrative Medical Sciences provide a whole-genome landscape of somatic alterations in 300 liver cancers from Japanese individuals. This comprehensive analysis identified point mutations, structural variations (STVs), and ...

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Clinical Significance of Long Intergenic Noncoding RNA-p21 in Colorectal Cancer

Long intergenic noncoding RNAs (lincRNAs) have been shown to be novel regulators for both transcription and posttranscriptional/translation. One of them, lincRNA-p21, was regulated by p53 and contributed to apoptosis in mouse embryonic fibroblasts. However, the impact of such regulation on colorectal cancer (CRC) remains to be determined. Now, researchers at the Stony Brook University have discovered that the expression level ...

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