Tag Archives: long intergenic non-coding RNAs

Long intergenic non-coding RNA expression signature in human breast cancer

lncrna

Breast cancer is a complex disease, characterized by gene deregulation. There is less systematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as biomarkers associated with breast cancer pathogenesis or several clinicopathological variables including receptor status and patient survival. Researchers at the Vanderbilt University Medical Center designed a two-stage study, including 1,000 breast tumor RNA-seq data from The ...

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Systematically characterizing dysfunctional long intergenic non-coding RNAs in multiple brain regions of major psychosis

lncRNA

Schizophrenia (SZ) and bipolar disorder (BD) are severe neuropsychiatric disorders with serious impact on patients, together termed “major psychosis”. Recently, long intergenic non-coding RNAs (lincRNAs) were reported to play important roles in mental diseases. However, little was known about their molecular mechanism in pathogenesis of SZ and BD. Here, researchers from Harbin Medical University performed RNA sequencing on 82 post-mortem ...

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Transcriptome sequencing uncovers altered long intergenic non-coding RNAs

Long intergenic non-coding RNAs (lncRNAs) represent an emerging and under-studied class of transcripts that play a significant role in human cancers. Due to the tissue- and cancer-specific expression patterns observed for many lncRNAs it is believed that they could serve as ideal diagnostic biomarkers. However, until each tumor type is examined more closely, many of these lncRNAs will remain elusive. ...

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BM742401 is a potent lincRNA inhibiting cancer metastasis

lncRNA

Long intergenic non-coding RNAs (lincRNAs) have historically been ignored in cancer biology. However, thousands of lincRNAs have been identified in mammals using recently developed genomic tools, including microarray and high-throughput RNA sequencing (RNA-Seq). Several of the lincRNAs identified have been well characterized for their functions in carcinogenesis. Here a team led by researchers at the Medical Genomics Research Center, KRIBB, ...

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Systematic study of human long intergenic non-coding RNAs and their impact on cancer

lincRNAs

The functional impact of several long intergenic non-coding RNAs (lincRNAs) has been characterized in previous studies. However, it is difficult to identify lincRNAs on a large-scale and to ascertain their functions or predict their structures in laboratory experiments because of the diversity, lack of knowledge and specificity of expression of lincRNAs. Furthermore, although there are a few well-characterized examples of ...

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Potential roles of microRNAs in regulating long intergenic noncoding RNAs

lincRNAs

Over 10,000 long intergenic non-coding RNAs (lincRNAs) have been identified in the human genome. Some have been well characterized and known to participate in various stages of gene regulation. In the post-transcriptional process, another class of well-known small non-coding RNA, or microRNA (miRNA), is very active in inhibiting mRNA. Though similar features between mRNA and lincRNA have been revealed in ...

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