Tag Archives: HOTAIR

Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen

lncRNA

The tumor microenvironment is a crucial determinant in tumor progression. Interstitial extracellular matrix (ECM), such as type I collagen (Col-1), is aberrantly enriched in the tumor microenvironment and promotes tumor progression. Long intergenic non-coding RNAs (lincRNA) are a new family of regulatory RNAs that modulate fundamental cellular processes via diverse mechanisms. Researchers at Tulane University School of Medicine investigated whether ...

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Long non-coding RNAs as targets for cytosine methylation

Post-synthetic modifications of nucleic acids have long been known to affect their functional and structural properties. For instance, numerous different chemical modifications modulate the structural organization, stability or translation efficiency of tRNAs and rRNAs. In contrast, little is known about modifications of poly(A)RNAs. Here, researchers from the Innsbruck Medical University, Austria demonstrate for the first time that the two well-studied ...

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Long noncoding RNAs – the search for function

In the late 1990s, before the publication of the human genome, John Rinn, then at Yale University, was hunting for protein genes on chromosome 22 with his graduate student adviser Michael Snyder. The only genes they found were ones that had already been discovered, but their arrays identified a steady stream of transcribed regions with no apparent purpose. These long ...

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