Tag Archives: heart failure

Biological ‘dark matter’ molecule plays surprise role in heart failure

lncRNA

Discovery may help scientists develop effective therapies to prevent or reverse this common and often fatal disease from the UCLA Newsroom by Jim Schnabel – Scientists at UCLA have identified a molecule that appears to play a key role in the development of heart failure. The scientists found that blocking the molecule, known as chaer, in animal studies prevented the ...

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Long noncoding RNAs in kidney and cardiovascular diseases

lncRNA

Transcription of a large part of the human genome results in RNA transcripts that have limited or no protein-coding potential. These include long noncoding RNAs (lncRNAs), which are defined as being ≥200 nucleotides long. Unlike microRNAs, which have been extensively studied, little is known about the functional role of lncRNAs. However, studies over the past 5 years have shown that ...

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Long Noncoding RNAs in Cardiovascular Diseases

lncRNA

In recent years, increasing evidence suggests that noncoding RNAs play important roles in the regulation of tissue homeostasis and pathophysiological conditions. Besides small noncoding RNAs (eg, microRNAs), >200-nucleotide long transcripts, namely long noncoding RNAs (lncRNAs), can interfere with gene expressions and signaling pathways at various stages. In the cardiovascular system, studies have detected and characterized the expression of lncRNAs under ...

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Missing links in cardiology: long non-coding RNAs enter the arena

Heart failure as a consequence of ischemic, hypertensive, infectious, or hereditary heart disease is a major challenge in cardiology and topic of intense research. Recently, new players appeared in this field and promise deeper insights into cardiac development, function, and disease. Long non-coding RNAs are a novel class of transcripts that can regulate gene expression and may have many more ...

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The Circulating Long Non-Coding RNA LIPCAR Predicts Survival in Heart Failure Patients

lncRNA

Long non-coding RNAs (lncRNAs) represent a novel class of molecules regulating gene expression. LncRNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease. A team led by researchers at the Hannover Medical School performed global transcriptomic analyses in plasma RNA from patients with/without left ventricular (LV)-remodeling after myocardial infarction. Regulated candidates were validated ...

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Decoding the Non-Coding Transcripts in Human Heart Failure

Heart failure (HF) is a complex disease with a broad spectrum of pathological features. Despite significant advancement in clinical diagnosis through improved imaging modalities and hemodynamic approaches, reliable molecular signatures for better differential diagnosis and for better monitoring of heart failure progression remain elusive. The few known clinical biomarkers for heart failure, such as plasma BNP and Troponin, have been ...

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Transcriptome Analysis Reveals Distinct Patterns of Long Noncoding RNAs in Heart and Plasma of Mice with Heart Failure

lncRNA

Researchers at the Peking University School of Basic Medical Sciences set out to assess the global changes in and characteristics of the transcriptome of long noncoding RNAs (LncRNAs) in heart tissue, whole blood and plasma during heart failure (HF) and association with expression of paired coding genes. The researchers used microarray assay to examine the transcriptome of LncRNAs deregulated in the ...

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