Tag Archives: heart disease

Patent Application Published – Diagnostic, Prognostic and Therapeutic Uses of Long Noncoding RNAs For Heart Disease and Regenerative Medicine

lncRNA

Document Type and Number: United States Patent Application 20160312283 Abstract: This invention generally relates to lncRNAs and methods for diagnosing cardiac pathologies in a subject. The invention also provides methods for treating a cardiac pathology in a subject comprising administering to said subject an effective amount of a modulator of one or more lncRNAs of the invention. Inventors: Ounzain, Samir ...

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Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy

lncRNA

Ischemic cardiomyopathy (ICM) resulting from myocardial infarction is a major cause of heart failure. Recently, thousands of long non-coding RNAs (lncRNAs) have been discovered and implicated in a variety of biological processes. However, the role of most lncRNAs in heart failure remains largely unknown. The aim of this study is to test the hypothesis that the expression and function of ...

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Webinar on lncRNAs advancing therapeutics for cancer and heart disease

lncRNA

The authors of two new high impact papers in Nature and Science Translational Medicine describe how long non-coding RNAs are providing new therapeutic avenues in cancer and heart disease. Prof. Thomas Thum Director of the Institute of Molecular and Translational Therapeutic Strategies Hannover Medical School, Germany Prof. Thum will describe results from the recent Science Translational Medicine paper demonstrating that ...

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Upcoming webinar – lncRNAs advancing therapeutics for cancer and heart disease

lncRNA

Join Exiqon on Thursday 9 June and hear the authors of two new high impact papers in Nature and Science Translational Medicine describe how long non-coding RNAs are providing new therapeutic avenues in cancer and heart disease. Prof. Jean-Christophe Marine from K.U. Leuven in Belgium will present results from the recent Nature paper showing that melanoma cancer cells are addicted ...

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Noncoding RNA May Help Treat Heart Disease

lncRNA

New research indicates that long noncoding RNAs (lncRNAs), a class of noncoding RNA larger than 200 nucleotides, may contribute to the development of cardiac hypertrophy (Viereck J et al. Sci Transl Med. 2016;8[326]:326ra2). After generating a whole-genome lncRNA profile to identify differentially expressed lncRNAs in heart muscle cells in a mouse model for pressure overload–induced cardiac hypertrophy and heart failure, ...

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Missing links in cardiology: long non-coding RNAs enter the arena

Heart failure as a consequence of ischemic, hypertensive, infectious, or hereditary heart disease is a major challenge in cardiology and topic of intense research. Recently, new players appeared in this field and promise deeper insights into cardiac development, function, and disease. Long non-coding RNAs are a novel class of transcripts that can regulate gene expression and may have many more ...

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Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs

Aim – Heart disease is recognized as a consequence of dysregulation of cardiac gene regulatory networks. Previously, unappreciated components of such networks are the long non-coding RNAs (lncRNAs). Their roles in the heart remain to be elucidated. Thus, this study aimed to systematically characterize the cardiac long non-coding transcriptome post-myocardial infarction and to elucidate their potential roles in cardiac homoeostasis. ...

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Long Noncoding RNA: a New Player of Heart Failure?

lncRNA

One the most important discoveries of the post-genomic era is that a large fraction of the genome transcribes a heterogeneous population of noncoding RNAs (ncRNA). ncRNAs shorter than 200 nucleotides are usually identified as short/small ncRNAs-examples include PIWI-interacting RNAs, small interfering RNAs, and microRNAs (miRNAs)-whereas those longer than 200 nucleotides are classified as long ncRNAs (lncRNAs). These molecules are emerging ...

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