Tag Archives: Harbin Institute of Technology

In Alzheimer’s Disease the majority of lncRNA genes may be transcriptionally regulated by histone modification

lncRNA

Increasing studies have revealed that long noncoding RNAs (lncRNAs) are not transcriptional noise but play important roles in the regulation of a wide range of biological processes, and the dysregulation of lncRNA genes is associated with disease development. Alzheimer’s disease (AD) is a chronic neurodegenerative disease that usually starts slowly and gets worse over time. However, little is known about ...

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LncRNA2Function – a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data

lncRNA

The GENCODE project has collected over 10,000 human long non-coding RNA (lncRNA) genes. However, the vast majority of them remain to be functionally characterized. Computational investigation of potential functions of human lncRNA genes is helpful to guide further experimental studies on lncRNAs. In this study, based on expression correlation between lncRNAs and protein-coding genes across 19 human normal tissues, researchers ...

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LncRNA2Target – a database for differentially expressed genes after lncRNA knockdown or overexpression

lncRNA

Long noncoding RNAs (lncRNAs) have been emerged as critical regulators of gene expression at epigenetic, transcriptional and post-transcriptional level, yet what genes are regulated by lncRNAs remains to be characterized. To assess the effects of a specific lncRNA on gene expression, increasing researchers profiled the genome-wide or individual gene expression level changes after knocking down or overexpressing the lncRNA. However, ...

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Long non-coding RNA identification by integrative modeling of chromatin and genomic features

lncRNA

In silico prediction of genomic long non-coding RNAs (lncRNAs) is prerequisite to the construction and elucidation of non-coding regulatory network. Chromatin modifications marked by chromatin regulators are important epigenetic features, which can be captured by prevailing high-throughput approaches such as ChIP sequencing. Researchers at the Harbin Institute of Technology and Harbin Medical University, China demonstrate that the accuracy of lncRNA ...

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