Tag Archives: GWAS

cis-Acting Complex-Trait-Associated lincRNA Expression Correlates with Modulation of Chromosomal Architecture

lncRNA

Intergenic long noncoding RNAs (lincRNAs) are the largest class of transcripts in the human genome. Although many have recently been linked to complex human traits, the underlying mechanisms for most of these transcripts remain undetermined. Researchers from the University of Lausanne investigated the regulatory roles of a high-confidence and reproducible set of 69 trait-relevant lincRNAs (TR-lincRNAs) in human lymphoblastoid cells ...

Read More »

Risk-associated SNPs promote prostate cancer through modulating lncRNA expression

Long noncoding RNAs (lncRNAs) represent an attractive class of candidates to mediate cancer risk. Through integrative analysis of the lncRNA transcriptome with genomic data and SNP data from prostate cancer genome-wide association studies (GWAS), researchers at the Princess Margaret Cancer Center identified 45 candidate lncRNAs associated with risk to prostate cancer. They further evaluated the mechanism underlying the top hit, ...

Read More »

Meta analysis of GWAS datasets reveals lung cancer risk lncRNA variant

lncRNA

Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. Duke University School of Medicine researchers performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium ...

Read More »

Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits

lncRNA

Long intergenic noncoding RNAs (lincRNAs) play important roles in disease, but the vast majority of these transcripts remain uncharacterized. A team led by researchers from Duke University defined a set of 54,944 human lincRNAs by drawing on four publicly available lincRNA datasets, and annotated ~2.5 million single-nucleotide polymorphisms from each of 15 cardiometabolic genome-wide association study datasets into these lincRNAs. ...

Read More »

Integrating Large-Scale RNA-Seq and CLIP-Seq Datasets Enables Study of lncRNA

Long non-coding RNAs (lncRNAs) are emerging as important regulatory molecules in developmental, physiological, and pathological processes. However, the precise mechanism and functions of most of lncRNAs remain largely unknown. Recent advances in high-throughput sequencing of immunoprecipitated RNAs after cross-linking (CLIP-Seq) provide powerful ways to identify biologically relevant protein-lncRNA interactions. In this study, researchers at Sun Yat-sen University analyzed millions of ...

Read More »

Transcriptomics to Therapeutics: Bridging the lncRNA Divide

Kip Harry Life Science Professional Join a focused discussion group on the therapeutic potential of lncRNA, addressing the following questions: Have exomes and RNA-Seq hindered, rather than helped, lncRNA disease genomics? How can we proceed from disease lncRNA discovery, in GWAS and functional studies, to translational therapeutics? Which of the currently known lncRNA mechanisms present the best opportunities for therapeutic ...

Read More »

Marcel Dinger – Lighting up the dark matter of the genome Unravelling the roles of noncoding DNA

Approximately 98% of the human genome comprises noncoding DNA, the function of which is largely unknown. Intriguingly, more than 85% of single nucleotide polymorphisms identified to be associated with disease in genome-wide studies (GWAS) occur within noncoding regions, suggesting that examining the role of these regions of the genome will be important for understanding and potentially treating disease (more…)

Read More »