Tag Archives: genomics

Termination of nuclear lncRNA transcription promotes mitochondrial genome maintenance

lncrna

Most DNA in the genomes of higher organisms does not code for proteins. RNA Polymerase II (Pol II) transcribes non-coding DNA into long non-coding RNAs (lncRNAs), but biological roles of lncRNA are unclear. Researchers at the University of Copenhagen found that mutations in the yeast lncRNA CUT60 result in poor growth. Defective termination of CUT60 transcription causes read-through transcription across the ...

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The Future of Biomarkers and Genomics

lncrna

from UroToday.com by  Zachary Klaassen, – Professor Manfred Wirth from Germany provided an update on the future of biomarkers and genomics at this afternoon’s EAU Update in Prostate Cancer in Vienna, Austria. Dr. Wirth divided his presentation into three subsections: Why are biomarkers needed for prostate cancer? There are several reasons according to Dr. Wirth why biomarkers are needed for prostate cancer, ...

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The lncRNome of head and neck squamous cell carcinomas

Long non-coding RNAs (lncRNAs) have emerged as key players in a remarkably variety of biological processes and pathologic conditions, including cancer. Next-generation sequencing technologies and bioinformatics procedures predict the existence of tens of thousands of lncRNAs, from which we know the functions of only a handful of them, and very little is known in cancer types such as head and ...

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lncRNA prostate cancer associated transcript-14 (PCAT-14) is prognostic for metastatic disease and survival

lncRNA

Long noncoding RNAs (lncRNAs) are an emerging class of relatively underexplored oncogenic molecules with biological and clinical significance. Current inadequacies for stratifying patients with aggressive disease presents a strong rationale to systematically identify lncRNAs as clinical predictors in localized prostate cancer. To identify RNA biomarkers associated with aggressive prostate cancer researchers from the Washington University School of Medicine obtained radical ...

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Post-doc position available – Computational lncRNA Genomics

Postdoctoral Research Scientist – Computational lncRNA Genomics MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, Oxford Grade 7: £29,837 – £36,661 with a discretionary range to £38,907 p.a. We are seeking a highly motivated and enthusiastic postdoctoral scientist to join Professor Chris Ponting’s research group in the internationally renowned MRC Functional Genomics Unit at the University of Oxford. ...

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Tissue-Specific RNA-Seq in Human Evoked Inflammation Identifies Blood and Adipose LincRNA Signatures

Inappropriate transcriptional activation of innate immunity is a pathological feature of several cardiometabolic disorders, but little is known about inflammatory modulation of long intergenic noncoding RNAs (lincRNAs) in disease-relevant human tissues. Researchers at the University of Pennsylvania applied deep RNA sequencing (>500 million filtered reads per sample) to blood and adipose during low-dose experimental endotoxemia (lipopolysaccharide) in a healthy human, ...

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Pseudogene lncRNAs are functional regulators of inflammatory signaling

lncRNA

Pseudogenes are thought to be inactive gene sequences, but recent evidence of extensive pseudogene transcription raised the question of potential function. Here researchers at the Stanford University School of Medicine discover and characterize the sets of mouse lncRNAs induced by inflammatory signaling via TNFα. TNFα regulates hundreds of lncRNAs, including 54 pseudogene lncRNAs, several of which show exquisitely selective expression ...

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