Tag Archives: genome

Genome regulation by long noncoding RNAs

lncRNA

NIH Director’s Wednesday Afternoon Lecture Series Dr. Chang’s research addresses how large sets of genes are turned on or off together, which is important in normal development, cancer, and aging. Chang discovered a new class of genes, termed long noncoding RNAs, can control gene activity throughout the genome, illuminating a new layer of biological regulation. He has invented new methods ...

Read More »

The RIDL hypothesis: transposable elements as functional domains of long noncoding RNAs

lncRNA

Our genome contains tens of thousands of long noncoding RNAs (lncRNAs), many of which are likely to have genetic regulatory functions. It has been proposed that lncRNA are organized into combinations of discrete functional domains, but the nature of these and their identification remain elusive. One class of sequence elements that is enriched in lncRNA is represented by transposable elements ...

Read More »

Long non-coding RNA in liver diseases

The identification of the presence of large RNA transcripts that do not code proteins but that may have biological functions has provided an important new perspective in gene regulation. These long non-coding RNAs (lncRNAs) are being increasingly recognized to contribute to many biological processes through diverse mechanisms. The roles of these emerging genes are being recognized across kingdoms. These findings ...

Read More »

Distinct patterns of genetic variations in potential functional elements in long noncoding RNAs

lncRNA

Non-protein coding RNAs have increasingly been shown to be an important class of regulatory RNAs having significant roles in regulation of gene expression. The long non-coding RNA gene family presently constitutes a large number of noncoding RNA loci almost equalling the number of protein-coding genes. Nevertheless the biological roles and mechanisms of majority of long noncoding RNAs are poorly understood, ...

Read More »

Cytotopic localization by long noncoding RNAs

lncRNA

Cells are highly organized structures. In addition to membrane delimited organelles, proteins and RNAs can organize themselves into specific domains. Some examples include stress granules and subnuclear bodies. This level of organization is essential for the correct execution of multiple processes in the cell, ranging from cell signaling to assembly of structures such as the ribosomes. Here the authors review ...

Read More »