Tag Archives: Genome Institute of Singapore

RNA and protein molecules join forces to switch on gene networks responsible for brain development


from Medical Xpress Long noncoding RNAs (lncRNAs) are one of many RNA subtypes that do not give rise to protein but instead modulate the expression of other genes. Scientists are particularly interested in lncRNAs owing to their prominent role in regulating how embryonic stem cells give rise to mature tissues. Lawrence Stanton and colleagues at the A*STAR Genome Institute of ...

Read More »

Scientists at Genome Institute of Singapore Discover Gene that Controls the Birth of Neurons

By ACN Newswire – August 27, 2013 10:36 PM EDT Discovery of long non-coding RNA’s role in neurogenesis may lead to cures for diseases such as Alzheimer’s disease Singapore, Aug 28, 2013 – (ACN Newswire) – Scientists at A*STAR’s Genome Institute of Singapore (GIS) have discovered an unusual gene that controls the generation of neurons[1]. This important finding, which is ...

Read More »

Featured long non-coding RNA – RMST

Long noncoding RNAs (lncRNAs) are abundant in the mammalian transcriptome, and many are specifically expressed in the brain. Researchers from the Genome Institute of Singapore and Harvard University have identified a group of lncRNAs, including rhabdomyosarcoma 2-associated transcript (RMST), which are indispensable for neurogenesis. Here, they provide mechanistic insight into the role of human RMST in modulating neurogenesis. RMST expression ...

Read More »

Featured long non-coding RNA – Dlx1as


Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer. This emerging importance of lncRNAs, along with recent reports of a functional lncRNA encoded by the mouse Dlx5-Dlx6 locus, led researchers at the ...

Read More »