Tag Archives: Genetic Engineering News

Long noncoding RNAs mean more than HOTAIR

From Genetic Engineering News by Patricia Fitzpatrick Dimond, Ph.D. Long noncoding RNA (lncRNAs) can regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels. Over the past 10 years, scientists say new methods, including deep sequencing and DNA tiling arrays, have enabled the identification and characterization of the human transcriptome. These techniques completely changed our understanding of genome organization and content ...

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Regional Epigenetic Down- and Up-Regulation in Cancer & lncRNAs with Potential Functionality

The focus of this GEN Market & Tech Analysis report is to present a snapshot of regional epigenetic down- and up-regulation in cancer with a focus toward prostate cancer. We present here long-range epigenetic silencing (LRES) as a means for downregulation of stretches of the genome as well as long-range epigenetic activation (LREA). These two opposing effects appear to be ...

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RNAi Screens and the Reagents That Enable Them

from Genetic Engineering News 2013 (Vol. 33, No. 19) by Jeanene Swanson RNAi screens for functional genomics typically look for loss- or gain-of-function phenotypes. They currently have many applications, including target discovery and validation, lead identification and optimization, mechanism of action discovery, predictive toxicology, and biomarker identification. While reagents are gaining ground, technical difficulties remain in how best to perform ...

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lncRNA space could be twice as big as the miRNA space

lncRNA

from Genetic Engineering News by Enal Razvi, Ph.D. Long Noncoding RNAs: Why You Need to Know about Them Now lncRNA space could be twice as big as the miRNA space as they seem to have tremendous potential as disease biomarkers. The focus of this GEN Market & Tech Analysis Report is to present some of our recent industry tracking of ...

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