Tag Archives: Function

Understanding the Functions of Long Non-Coding RNAs through Their Higher-Order Structures

lncRNA

Although thousands of long non-coding RNAs (lncRNAs) have been discovered in eukaryotes, very few molecular mechanisms have been characterized due to an insufficient understanding of lncRNA structure. Therefore, investigations of lncRNA structure and subsequent elucidation of the regulatory mechanisms are urgently needed. However, since lncRNA are high molecular weight molecules, which makes their crystallization difficult, obtaining information about their structure ...

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Unique features of long non-coding RNA biogenesis and function

lncRNA

The transcriptional landscape of all organisms is far more complex than was originally imagined, as the vast majority of genomic sequence is pervasively transcribed into a diverse range of protein-coding RNAs and non-coding RNAs (ncRNAs). In this expanded view of both the genome and the transcriptome, our catalogue of genetic elements is now brimming with long non-coding RNAs (lncRNAs), a ...

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Upcoming Conference – Long Noncoding RNAs: From Evolution to Function

lncrna

Scientific Organizers: Leonard Lipovich, Jeannie T. Lee, John L. Rinn and James (Ben) Brown March 15—20, 2015 Keystone Resort, Keystone, Colorado, USA Sponsored by Cell Research, Isis Pharmaceuticals, Inc., Regeneron Pharmaceuticals, Inc. and Sarepta Therapeutics Meeting Summary It has become clear that metazoan genomes are replete with transcription from non-protein-coding regions, generating many long noncoding RNA (lncRNA) transcripts. Recent progress ...

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lncRNAMap: A map of putative regulatory functions in the long non-coding transcriptome

lncRNA

lncRNAMap is an integrated and comprehensive database relating to exploration of the putative regulatory functions of human lncRNAs with two mechanisms of regulation, by encoding siRNAs and by acting as miRNA decoys. To investigate lncRNAs producing siRNAs that regulate protein-coding genes, lncRNAMap integrated small RNAs (sRNAs) that were supported by publicly available deep sequencing data from various sRNA libraries and ...

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