Tag Archives: evolution

On the evolution and function of lncRNAs

lncRNA

from International Innovation by Hao Zhu – Researchers from Southern Medical University, China, have developed an effective computational approach that helps elucidate long non-coding RNAs’ DNA binding motifs and binding sites Professor Hao Zhu describes his work on the evolution and function of long non-coding RNAs, explaining how his new computational approach could provide novel information towards an improved understanding ...

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Dynamic and widespread lncRNA expression in the sponge and the origin of animal complexity

lncRNA

Long non-coding RNAs (lncRNAs) are important developmental regulators in bilaterian animals. A correlation has been claimed between the lncRNA repertoire expansion and morphological complexity in vertebrate evolution. However, this claim has not been tested by examining morphologically simple animals. Here, researchers from the University of Queensland undertake a systematic investigation of lncRNAs in the demosponge Amphimedon queenslandica, a morphologically-simple, early-branching ...

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Upcoming Conference – Long Noncoding RNAs: From Evolution to Function

lncrna

Scientific Organizers: Leonard Lipovich, Jeannie T. Lee, John L. Rinn and James (Ben) Brown March 15—20, 2015 Keystone Resort, Keystone, Colorado, USA Sponsored by Cell Research, Isis Pharmaceuticals, Inc., Regeneron Pharmaceuticals, Inc. and Sarepta Therapeutics Meeting Summary It has become clear that metazoan genomes are replete with transcription from non-protein-coding regions, generating many long noncoding RNA (lncRNA) transcripts. Recent progress ...

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The RIDL hypothesis: transposable elements as functional domains of long noncoding RNAs

lncRNA

Our genome contains tens of thousands of long noncoding RNAs (lncRNAs), many of which are likely to have genetic regulatory functions. It has been proposed that lncRNA are organized into combinations of discrete functional domains, but the nature of these and their identification remain elusive. One class of sequence elements that is enriched in lncRNA is represented by transposable elements ...

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The evolution of lncRNA repertoires and expression patterns in tetrapods

lncRNA

Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative analyses. Here researchers at the University of Lausanne, Switzerland present a large-scale evolutionary study of lncRNA repertoires and expression patterns, in 11 tetrapod species. ...

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Knockout Mice Study: Long Noncoding RNAs "Play Central Roles in Mammalian Development and Physiology"

lncRNA

by Casey Luskin at Evolution News & Views A few years ago I wrote about challenges to the claim that “junk DNA” wasn’t necessary for development. In experiments with mice, researchers had supposedly “knocked out” non-coding DNA, yet the mice themselves as they grew turned out to be healthy. Now a new study in eLife, “Multiple knockout mouse models reveal ...

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Genetics Is Too Complex for Evolutionists to Fake It Anymore

lncRNA

from Evolution News & Views As David Klinghoffer noted the other day, a well-known science journalist has had it with evolutionary pretensions. It’s time to stop the “scientists now know” show and, rather, honestly “Celebrate the Unknowns.” This article deserves special emphasis — it’s that good. Writing in Nature on the 60th anniversary of the elucidation of the DNA molecule’s ...

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