Tag Archives: ENCODE

Many viruses activate a single RNA to enable successful infections

lncrna

from ARS Technica – Viruses co-opt one of a cell’s long noncoding RNAs to replicate A gene is a DNA sequence that encodes the instructions for when and where to make a particular protein. But most of the DNA in our genome—well over ninety percent—is not composed of genes. The argument over the role of this seemingly extraneous DNA has swung back and ...

Read More »

Protracted Unrest Between ENCODE Researchers and Junk-DNA Advocates Goes On

lncRNA

from Evolution News and Views It’s not exactly Fergusson, Mo., but the battle between ENCODE researchers and junk-DNA holdouts goes on. Our ongoing coverage of the hostilities left off with the latter sending over their latest salvo. Now, ENCODE is back. Confident that genomes are not mostly junk, they have set their latest contender in the ring: a mouse. The ...

Read More »

TF2LncRNA: Identifying Common Transcription Factors for a List of lncRNA Genes from ChIP-Seq Data

lncrna

High-throughput genomic technologies like lncRNA microarray and RNA-Seq often generate a set of lncRNAs of interest, yet little is known about the transcriptional regulation of the set of lncRNA genes. Here, based on ChIP-Seq peak lists of transcription factors (TFs) from ENCODE and annotated human lncRNAs from GENCODE, researchers from the Harbin Institute of Technology have developed a web-based interface ...

Read More »

Cedric Notredame: “We want to understand under what pressure evolves long noncoding RNA”

According to the ENCODE‘s latest update in the human genome there are about 10,000 long sequences of RNA that do not code for any protein. Cedric Notredame’s lab at the Center for genomic Regulation (CRG) tries to detect these molecules not only in humans but also in other species to understand their functionality. Cedric Notredame explained his research at a ...

Read More »