Tag Archives: embryonic stem cells

Long Noncoding RNA Moderates MicroRNA Activity to Maintain Self-Renewal in Embryonic Stem Cells

lncrna

Of the thousands of long noncoding RNAs expressed in embryonic stem cells (ESCs), few have known roles and fewer have been functionally implicated in the regulation of self-renewal and pluripotency, or the reprogramming of somatic cells to the pluripotent state. In ESCs, Cyrano is a stably expressed long intergenic noncoding RNA with no previously assigned role. Researchers from the University ...

Read More »

Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease

Comprehensive analysis of the mammalian transcriptome has revealed that long non-coding RNAs (lncRNAs) may make up a large fraction of cellular transcripts. Recent years have seen a surge of studies aimed at functionally characterizing the role of lncRNAs in development and disease. In this review, the authors discuss new findings implicating lncRNAs in controlling development of the central nervous system ...

Read More »

Upcoming Seminar – Long noncoding RNA: transcription noise or biological modulator? A view from studies in embryonic stem cells

Dr. Xiaohua Shen, Associate Professor Tsinghua University, Beijing, China Wednesday, June 25, 2014 – 11:00am CCBR Red Room Abstract: Pervasive transcription in mammalian genome produces thousands of long noncoding RNA (lncRNA) transcripts. It has been hypothesized that lncRNAs as versatile modulators regulate diverse aspects of biology. However, their biological significance remains skeptical due to healthy concerns of subtle phenotypic differences ...

Read More »