Tag Archives: dna damage

An inducible long noncoding RNA amplifies DNA damage signaling

lncRNA

Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but mostly unknown functions. Here researchers from Stanford University School of Medicine demonstrate that lncRNAs guide the organismal DNA damage response. DNA damage activated transcription of the DINO (Damage Induced Noncoding) lncRNA via p53. DINO was required for p53-dependent gene expression, cell cycle arrest and apoptosis in response to ...

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