Tag Archives: DKFZ

Post-doc position available – bioinformatics of long noncoding RNAs

lncrna

The Institute for Computational Genomics, RWTH Aachen University performs cutting edge research on computational and genomic methods for understanding regulatory and epigenetic processes driving cell differentiation and diseases. We are particularly interested in studying RNA-DNA interactions as mechanisms of transcriptional control. For example, we have recently shown how the long-noncoding RNA HOTAIR interacts with DNA via triple helices to control ...

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Challenges of CRISPR/Cas9 applications for long non-coding RNA genes

lncRNA

Long non-coding RNAs (lncRNAs) represent a large subgroup of RNAs that are over 200 nucleotides long and have a limited protein-coding potential. They play an important role in diverse cellular processes by regulating the gene expression at transcriptional or post-transcriptional levels. This ability of lncRNAs to modulate gene expression renders them indispensable for normal development CRISPRs (Clustered Regularly Interspaced Palindromic ...

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