Tag Archives: disease

FMLNCSIM – fuzzy measure-based lncRNA functional similarity calculation model

lncRNA

Accumulating experimental studies have indicated the influence of lncRNAs on various critical biological processes as well as disease development and progression. Calculating lncRNA functional similarity is of high value in inferring lncRNA functions and identifying potential lncRNA-disease associations. However, little effort has been attempt to measure the functional similarity among lncRNAs on a large scale. Now, researchers have developed a ...

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Environmental Health and Long Non-coding RNAs

lncRNA

An individual’s risk of developing a common disease typically depends on an interaction of genetic and environmental factors. Epigenetic research is uncovering novel ways through which environmental factors such as diet, air pollution, and chemical exposure can affect our genes. DNA methylation and histone modifications are the most commonly studied epigenetic mechanisms. The role of long non-coding RNAs (lncRNAs) in ...

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ILNCSIM – improved lncRNA functional similarity calculation model

lncRNA

Increasing observations have indicated that lncRNAs play a significant role in various critical biological processes and the development and progression of various human diseases. Constructing lncRNA functional similarity networks could benefit the development of computational models for inferring lncRNA functions and identifying lncRNA-disease associations. However, little effort has been devoted to quantifying lncRNA functional similarity. In this study, researchers at ...

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Long non-coding RNA in health and disease

lncRNA

Long non-coding RNAs (lncRNAs) interact with the nuclear architecture and are involved in fundamental biological mechanisms, such as imprinting, histone-code regulation, gene activation, gene repression, lineage determination, and cell proliferation, all by regulating gene expression. Understanding the lncRNA regulation of transcriptional or post-transcriptional gene regulation expands our knowledge of disease. Several associations between altered lncRNA function and gene expression have ...

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Integrating the roles of long and small non-coding RNA in brain function and disease

lncRNA

Regulatory RNA is emerging as the major architect of cognitive evolution and innovation in the mammalian brain. While the protein machinery has remained largely constant throughout animal evolution, the non protein-coding transcriptome has expanded considerably to provide essential and widespread cellular regulation, partly through directing generic protein function. Both long (long non-coding RNA) and small non-coding RNAs (for example, microRNA) ...

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Distinct patterns of genetic variations in potential functional elements in long noncoding RNAs

lncRNA

Non-protein coding RNAs have increasingly been shown to be an important class of regulatory RNAs having significant roles in regulation of gene expression. The long non-coding RNA gene family presently constitutes a large number of noncoding RNA loci almost equalling the number of protein-coding genes. Nevertheless the biological roles and mechanisms of majority of long noncoding RNAs are poorly understood, ...

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