Tag Archives: diabetes

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

lncRNA

Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In ...

Read More »

Transcriptome analyses identifies long noncoding RNAs regulating energy metabolism

lncRNA

  Genome-wide screens define 359 metabolically sensitive lncRNAs in key metabolic organs LncRNA functions were predicted by mRNA-lncRNA correlation analyses In vitro assays connect lncRNAs to specific metabolic and signaling pathways SREBP1c induces Gm16551 to activate an lncRNA-mediated negative feedback loop       To systemically identify long noncoding RNAs (lncRNAs) regulating energy metabolism, researchers from the National Heart, Lung and ...

Read More »