Tag Archives: colon cancer

Post-doc Position Available – Digestive Diseases

lncRNA

David Geffen School Of Medicine – Medicine-Gastroenterology Recruitment Period – Open August 17th, 2017 through November 17th, 2017 Description The Padua lab has a keen interest in understanding gene regulation and signaling pathways in the context of complex biological phenomena. Our clinical interests are in inflammatory bowel disease (IBD) and colon cancer diagnosis. One focus of the lab will be ...

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lncRNA MYU plays a critical role in the proliferation and tumorigenicity of colon cancer cells.

lncRNA

Aberrant activation of Wnt/β-catenin signaling is a major driving force in colon cancer. Wnt/β-catenin signaling induces the expression of the transcription factor c-Myc, leading to cell proliferation and tumorigenesis. c-Myc regulates multiple biological processes through its ability to directly modulate gene expression. Here, researchers from the University of Tokyo identify a direct target of c-Myc, termed MYU, and show that ...

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Long Non-Coding RNA H19 Promotes Glioma Cell Invasion by Deriving miR-675

lncRNA

H19 RNA has been characterized as an oncogenic long non-coding RNA (lncRNA) in breast and colon cancer. However, the role and function of lncRNA H19 in glioma development remain unclear. In this study, scientists from the First Affiliated Hospital of Nanjing Medical University identified that H19/miR-675 signaling was critical for glioma progression. By analyzing glioma gene expression data sets, they ...

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Malignant transformation of colonic epithelial cells by a colon-derived long noncoding RNA

Recent progress has been made in the identification of protein-coding genes and miRNAs that are expressed in and alter the behavior of colonic epithelia. However, the role of long non-coding RNAs (lncRNAs) in colonic homeostasis is just beginning to be explored. By gene expression profiling of post-mitotic, differentiated tops and proliferative, progenitor-compartment bottoms of microdissected adult mouse colonic crypts, we ...

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Peptide nucleic acid (PNA) based molecular beacons as diagnostic probes

Molecular Beacons

Although the function and mechanism of action of long non-coding RNAs (lncRNA) is still not completely known, studies have shown their potential role in the control of gene expression and regulation, in cellular proliferation and invasiveness at the transcriptional level via multiple mechanisms. Recently, colon cancer associated transcript 1 (CCAT1) lncRNA was found to be expressed in colorectal cancer (CRC) ...

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