Tag Archives: cisplatin

Featured Long non-coding RNA – UCA1

Chemotherapy is a reasonable alternative to cystectomy in patients with invasive and advanced bladder cancer. However, bladder cancer cells often develop drug resistance to these therapies and approximately 50% of patients with advanced bladder cancer do not respond to chemotherapy. Recent studies show that long-noncoding RNA (lncRNA) is involved in the development of chemoresistance. Here researchers from the Shanghai Jiaotong ...

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Identification of short-lived long non-coding RNAs as surrogate indicators for chemical stress response

Abiotic and biotic stressors in human cells are often a result of sudden and/or frequent changes in environmental factors. The molecular response to stress involves elaborate modulation of gene expression and is of homeostatic, ecological, and evolutionary importance. Although attention has primarily focused on signaling pathways and protein networks, long non-coding RNAs (ncRNAs) are increasingly involved in the molecular mechanisms ...

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