Tag Archives: Chinese Academy of Sciences

Panel of seven long noncoding RNA as a candidate prognostic biomarker for ovarian cancer

lncRNA

Ovarian cancer is one of the most common and lethal gynecological malignancies. The diagnosis of ovarian cancer is often at an advanced stage. Accumulated evidence suggests that long noncoding RNAs (lncRNAs) play important roles during ovarian tumorigenesis. In this study, using the lncRNA-mining approach, researchers from the Chinese Academy of Sciences and Fudan University analyzed lncRNA expression profiles of 493 ...

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Identification and function annotation of long intervening noncoding RNAs

RNA-seq technology offers the promise of rapid comprehensive discovery of long intervening noncoding RNAs (lincRNAs). Basic tools such as Tophat and Cufflinks have been widely used for RNA-seq assembly. However, advanced bioinformatics methodologies that allow in-depth analysis of lincRNAs are lacking. Here, researchers from the Chinese Academy of Sciences describe a computational protocol that is especially designed for the identification ...

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Community Curated Database For LncRNA

lncRNA

A wiki-style database hopes to serve as an online encyclopedia of lncRNA by and for the scientific community. Scientists have set up a long non-coding RNA (lncRNA) database aimed at harnessing the collective knowledge of the scientific community. This study has been published in Nucleic Acids Research. LncRNAs are RNAs that do not code for proteins but are nonetheless actively ...

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A Computational Framework to Infer Human Disease-Associated Long Noncoding RNAs

lncRNA

As a major class of noncoding RNAs, long noncoding RNAs (lncRNAs) have been implicated in various critical biological processes. Accumulating researches have linked dysregulations and mutations of lncRNAs to a variety of human disorders and diseases. However, to date, only a few human lncRNAs have been associated with diseases. Therefore, it is very important to develop a computational method to ...

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Circular Intronic Long Noncoding RNAs

lncRNA

Researchers from the Chinese Academy of Sciences describe the identification and characterization of circular intronic long noncoding RNAs in human cells, which accumulate owing to a failure in debranching. The formation of such circular intronic RNAs (ciRNAs) can be recapitulated using expression vectors, and their processing depends on a consensus motif containing a 7 nt GU-rich element near the 5′ ...

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LRLSLDA: Laplacian Regularized Least Squares for LncRNA-Disease Association

More and more evidences have indicated that long-non-coding RNAs (lncRNAs) play critical roles in many important biological processes. Therefore, mutations and dysregulations of these lncRNAs would contribute to the development of various complex diseases. Developing powerful computational models for potential disease related lncRNAs identification would benefit biomarker identification and drug discovery for human disease diagnosis, treatment, prognosis and prevention. In ...

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Wide-spread long non-coding RNAs (lncRNAs) as endogenous target mimics (eTMs) for microRNAs in plants

Target mimicry is a recently identified regulatory mechanism for microRNA functions in plants in which the decoy RNAs bind to microRNAs via sequence complementary therefore to block the interaction between microRNAs and their authentic targets. Both endogenous decoy RNAs (microRNA target mimics) and engineered artificial RNAs can induce target mimicry effects. Yet until now, only the IPS1 (Induced by Phosphate ...

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