Tag Archives: Chemoresistance

lncRNA HANR promotes tumorigenesis and increase of chemoresistance

lncRNA

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer-related death. Critical roles for long non-coding RNAs (lncRNAs) have recently been demonstrated for a variety of cancers, including hepatocellular carcinoma. However, the effect and mechanism of lncRNAs in HCC tumorigenesis and chemoresistance have not been extensively characterized. In the current study, ...

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Researchers Show Curcumin Protects Against Chemoresistant Pancreatic Cancer Through lncRNA

lncRNA

Curcumin is known for its powerful anti-inflammatory and antioxidant benefits, but a new study by researchers at Baylor Scott & White Research Institute reveals an additional benefit: its potential to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC), a common but aggressive form of cancer in the pancreas. The study, “Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit ...

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The Influence of microRNAs and Long Non-Coding RNAs in Cancer Chemoresistance

lncRNA

Innate and acquired chemoresistance exhibited by most tumours exposed to conventional chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such chemoresistance phenotypes are of a multi-factorial nature from multiple key molecular players. The discovery of the RNA interference pathway in 1998 and the widespread gene regulatory influences exerted by microRNAs (miRNAs) and other non-coding RNAs have ...

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Featured Long non-coding RNA – UCA1

Chemotherapy is a reasonable alternative to cystectomy in patients with invasive and advanced bladder cancer. However, bladder cancer cells often develop drug resistance to these therapies and approximately 50% of patients with advanced bladder cancer do not respond to chemotherapy. Recent studies show that long-noncoding RNA (lncRNA) is involved in the development of chemoresistance. Here researchers from the Shanghai Jiaotong ...

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