Tag Archives: Chaer

Linc-ing the Noncoding Genome to Heart Function

lncrna

Cardiovascular disease is a major health concern worldwide. Hypertensive stress, inflammation or injury of heart muscle, and abnormal rhythms due to valve dysfunction can contribute to the enlargement of cardiac cells known as ‘pathological’ hypertrophy. Pathological hypertrophy can further lead to fibrosis or scarring of tissue, reduced capillary densities, increased levels of proinflammatory cytokines, dysregulation of signaling pathways, autophagy, and ...

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Long Noncoding RNAs in Pathological Cardiac Remodeling

lncRNA

DNA makes RNA, RNA makes protein, and protein makes us. This central dogma of life provides a simple description how an organism develops: DNA serves as a blueprint of the genetic information, and proteins are its functional and structural manifestation, whereas RNA mediates this process as a plotted construction plan. However, the relation between the genetic code and its biological ...

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Biological ‘dark matter’ molecule plays surprise role in heart failure

lncRNA

Discovery may help scientists develop effective therapies to prevent or reverse this common and often fatal disease from the UCLA Newsroom by Jim Schnabel – Scientists at UCLA have identified a molecule that appears to play a key role in the development of heart failure. The scientists found that blocking the molecule, known as chaer, in animal studies prevented the ...

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The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy

lncRNA

Epigenetic reprogramming is a critical process of pathological gene induction during cardiac hypertrophy and remodeling, but the underlying regulatory mechanisms remain to be elucidated. Here a team led by researchers at UCLA identified a heart-enriched long noncoding (lnc)RNA, named cardiac-hypertrophy-associated epigenetic regulator (Chaer), which is necessary for the development of cardiac hypertrophy. Mechanistically, Chaer directly interacts with the catalytic subunit ...

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