Tag Archives: ceRNA network

Systematical analysis of lncRNA-mRNA competing endogenous RNA network in breast cancer subtypes

lncrna

Breast cancer is one of the most common solid tumors in women involving multiple subtypes. However, the mechanism for subtypes of breast cancer is still complicated and unclear. Recently, several studies indicated that long non-coding RNAs (lncRNAs) could act as sponges to compete miRNAs with mRNAs, participating in various biological processes. Researchers at the Nanjing University of Aeronautics and Astronautics ...

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Comprehensive characterization of lncRNA-mRNA related ceRNA network across 12 major cancers

lncRNA

Recent studies indicate that long noncoding RNAs (lncRNAs) can act as competing endogenous RNAs (ceRNAs) to indirectly regulate mRNAs through shared microRNAs, which represents a novel layer of RNA crosstalk and plays critical roles in the development of tumor. However, the global regulation landscape and characterization of these lncRNA related ceRNA crosstalk in cancers is still largely unknown. Here, researchers ...

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A dysregulated lncRNA-associated ceRNA network identifies novel lncRNA cancer biomarkers

lncRNA

It is increasing evidence that ceRNA activity of long non-coding RNAs (lncRNAs) played critical roles in both normal physiology and tumorigenesis. However, functional roles and regulatory mechanisms of lncRNAs as ceRNAs in pancreatic ductal adenocarcinoma (PDAC), and their potential implications for early diagnosis remain unclear. In this study, Harbin Medical University researchers performed a genome-wide analysis to investigate potential lncRNA-mediated ...

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A functional GBM long non-coding RNA-mediated competitive endogenous RNA network

lncRNA

Glioblastoma multiforme (GBM) is a highly malignant brain tumor associated with a poor prognosis. Cross-talk between competitive endogenous RNAs (ceRNAs) plays a critical role in tumor development and physiology. In this study, researchers at Xiangya Hospital present a multi-step computational approach to construct a functional GBM long non-coding RNA (lncRNA)-mediated ceRNA network (LMCN) by integrating genome-wide lncRNA and mRNA expression ...

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