Tag Archives: Cell Proliferation

lncRNA-HIT promotes cell proliferation of non-small cell lung cancer

Lung cancer is the leading cause of cancer-related death around the world. Long noncoding RNA (lncRNA) has pivotal roles in cancer occurrence and development. However, only a few lncRNAs have been functionally characterized. Jilin University researchers investigated the effects of lncRNA-HIT (HOXA transcript induced by TGFβ) expression on non-small cell lung cancer (NSCLC) cell phenotype with the gain-of-function and loss-of-function ...

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Featured Long non-coding RNA: GHET1

Long noncoding RNAs (lncRNAs), a recently characterized class of noncoding RNAs, have been shown to have important regulatory roles and are deregulated in a variety of tumors. However, the contributions and functional mechanisms of lncRNAs to gastric carcinoma remain largely unknown. In this study, researchers at the Shanghai Jiao Tong University School of Medicine, China found that lncRNA gastric carcinoma ...

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Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer

Long non-coding RNAs (lncRNAs) are emerging as key molecules in human cancer. Highly upregulated in liver cancer (HULC), an lncRNA, has recently been revealed to be involved in hepatocellular carcinoma development and progression. It remains unclear, however, whether HULC plays an oncogenic role in human gastric cancer (GC). In the present study, researchers at the First Affiliated Hospital of Nanjing ...

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Featured Long Noncoding RNA – ANRASSF1


RASSF1A is a tumor suppressor gene whose expression is repressed through epigenetic events in a wide range of different cancers. Repression is effected by DNA hypermethylation of the RASSF1A promoter, which in turn is triggered through histone H3K9/H3K27 trimethylation repressive marks. The addition of the H3K27me3 mark at the RASSF1A promoter locus involves the polycomb repressive complex 2 (PRC2). The ...

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