Tag Archives: breast cancer

Pathway Responsible For Breast Cancer Metastasis Identified By MD Anderson Researchers

lncRNA

from Breast Cancer News Scientists at The University of Texas MD Anderson Cancer Center have discovered a signalling pathway responsible for breast cancer metastasis. The study, led by Liuqing Yang, Ph.D., assistant professor of molecular and cellular oncology, was published in this month’s issue of Cell.  Molecules called long non-coding RNAs (lncRNAs) are known because of their role in metastasis and tumor growth. However, until now, the dimensions ...

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Emerging Role of Long Non-Coding RNA SOX2OT in SOX2 Regulation in Breast Cancer

The transcription factor SOX2 is essential for maintaining pluripotency in a variety of stem cells. It has important functions during embryonic development, is involved in cancer stem cell maintenance, and is often deregulated in cancer. The mechanism of SOX2 regulation has yet to be clarified, but the SOX2 gene lies in an intron of a long multi-exon non-coding RNA called ...

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Long non-coding RNA UCA1 promotes breast tumor growth

lncRNA

Functional genomics studies have led to the discovery of a large amount of non-coding RNAs from the human genome; among them are long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs could have a critical role in the regulation of cellular processes such as cell growth and apoptosis as well as cancer progression and metastasis. As master gene regulators, lncRNAs ...

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Long Non-Coding RNA H19 Promotes Glioma Cell Invasion by Deriving miR-675

lncRNA

H19 RNA has been characterized as an oncogenic long non-coding RNA (lncRNA) in breast and colon cancer. However, the role and function of lncRNA H19 in glioma development remain unclear. In this study, scientists from the First Affiliated Hospital of Nanjing Medical University identified that H19/miR-675 signaling was critical for glioma progression. By analyzing glioma gene expression data sets, they ...

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Featured long non-coding RNA-ARA: Adriamycin Resistance Associated

Long non-coding RNAs (lncRNAs) are emerging as an integral functional component of human genome and have been investigated as critical regulators in molecular biology of cancer. A recent study reported that lncRNA-UCA1 induced drug resistance in adriamycin chemotherapy. However, the contributions of lncRNAs to adriamycin resistance in cancers remain largely unknown. To address this issue, researchers at the First Affiliated ...

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Featured long non-coding RNA: lncRNA-JADE

A prompt and efficient DNA damage response (DDR) eliminates the detrimental effects of DNA lesions in eukaryotic cells. Basic and preclinical studies suggest that the DDR is one of the primary anti-cancer barriers during tumorigenesis. The DDR involves a complex network of processes that detect and repair DNA damage, in which long non-coding RNAs (lncRNAs), a new class of regulatory ...

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Regulation of lncRNA expression by miRNA

lncRNA

In addition to protein-coding genes, the human genome makes a large amount of noncoding RNAs, including microRNAs and long noncoding RNAs (lncRNAs). Both microRNAs and lncRNAs have been shown to have a critical role in the regulation of cellular processes such as cell growth and apoptosis, as well as cancer progression and metastasis. Although it is well known that microRNAs ...

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Potential roles of microRNAs in regulating long intergenic noncoding RNAs

lincRNAs

Over 10,000 long intergenic non-coding RNAs (lincRNAs) have been identified in the human genome. Some have been well characterized and known to participate in various stages of gene regulation. In the post-transcriptional process, another class of well-known small non-coding RNA, or microRNA (miRNA), is very active in inhibiting mRNA. Though similar features between mRNA and lincRNA have been revealed in ...

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