Tag Archives: breast cancer

lncRNAs – novel candidate biomarkers to identify breast cancer patients at high risk of tumor recurrence

lncRNA

Deregulation of long non-coding RNAs (lncRNAs) expression has been proven to be involved in the development and progression of cancer. However, expression pattern and prognostic value of lncRNAs in breast cancer recurrence remain unclear. Here, researchers from Harbin Medical University analyzed lncRNA expression profiles of breast cancer patients who did or did not develop recurrence by repurposing existing microarray datasets from ...

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OSBREAC research yields a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer

lncRNA

Long noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, basal-like subtype associates with increased EGFR signaling, while another, the HER2-enriched subtype, engages a kin of EGFR Based on the premise that EGFR-regulated lncRNAs might control the aggressiveness of basal-like ...

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HOTAIR is a novel biomarker of response to endocrine therapy for estrogen receptor positive breast cancer patients

lncrna

Predicting response to endocrine therapy and survival in estrogen receptor positive breast cancer is a significant clinical challenge and novel prognostic biomarkers are needed. Long-range regulators of gene expression are emerging as promising biomarkers and therapeutic targets for human diseases, so researchers at the University of Queensland have explored the potential of distal enhancer elements of non-coding RNAs in the ...

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Transcriptome sequencing uncovers a three-long noncoding RNA signature in predicting breast cancer survival

lncRNA

Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. The aim of this study was to identify a lncRNA signature that can predict breast cancer patient survival. RNA expression data from 1064 patients were downloaded from The Cancer Genome Atlas project. Cox regression, Kaplan-Meier, and receiver operating characteristic (ROC) analyses were performed to construct a model for predicting the ...

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Targeting a Long Noncoding RNA in Breast Cancer

lncRNA

The central dogma of molecular biology posits that genes are transcribed into messenger RNA (mRNA), which is then translated into proteins, which, in turn, are ultimately responsible for all cellular functions. Yet recent research has revealed that RNAs that do not encode proteins — known as noncoding RNAs — play important roles in normal physiological processes and can contribute to ...

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NEAT1 is Required for Survival of Breast Cancer Cells

Increasing evidence shows that long noncoding RNAs (lncRNAs) have important roles in the regulation of multiple cellular processes, including cell division, cell growth, and apoptosis, as well as cancer metastasis and neurological disease progression; however, the mechanism of how lncRNAs regulate these processes is not well established. In this study, researchers from the Chinese Academy of Sciences demonstrated that downregulating ...

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A Long-noncoding RNA Regulates Repair of DNA Breaks in Triple-Negative Breast Cancer Cells

lncrna

LINP1 enhances the repair of DNA breaks by serving as a scaffold that links two other proteins in the repair machinery. Findings give “new insight” into biology of tough-to-treat breast cancer PHILADELPHIA – The discovery of long non-coding RNA (lncRNA) has dramatically changed the understanding of the biology of diseases such as cancer. The human genome contains about 20,000 protein-coding ...

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Knockdown of long noncoding RNAs in breast cancer

Traditionally genetics has held a protein centric view with RNA seen as an intermediate step between DNA and protein. Recently, the emerging evidence of pervasive transcription throughout the genome has challenged this view1,2. Long noncoding RNAs (lncRNA) are selectively expressed during different cell cycles3 as well as transcribed differently in specific cell types4, which emphasizes their importance in regulating cell ...

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‘Junk’ DNA plays role in preventing breast cancer

from Laboratory News – Dr Adele Murrell fills us in on a new approach to making sense of “junk” DNA and RNA “noise” to fight cancer.Our DNA is what makes us who we are and the central dogma underpinning genetics is that genes are encoded by DNA, the code is copied into RNA which is then decoded to build proteins. ...

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Unveiling a new factor that helps breast cancer cells to tolerate drugs

lncRNA

from biotechin.asia by Mohamad Moustafa Ali Breast cancer is one of the most divergent and heterogeneous genetic disorders that affects hundreds of thousands of women worldwide every year. Scientists have systematically classified breast cancer tumors into different types, whereas each type possesses different characteristic features. Among these different types, endocrine receptor-positive (ER+) is the most common one. The ER+ breast ...

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