Tag Archives: breast cancer

Long intergenic non-coding RNA expression signature in human breast cancer

lncrna

Breast cancer is a complex disease, characterized by gene deregulation. There is less systematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as biomarkers associated with breast cancer pathogenesis or several clinicopathological variables including receptor status and patient survival. Researchers at the Vanderbilt University Medical Center designed a two-stage study, including 1,000 breast tumor RNA-seq data from The ...

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Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer

lncrna

Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, Indiana University researchers analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. They revealed two distinctive co-expression patterns associated with breast cancer, reflecting different underlying regulatory mechanisms: (1) ...

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Exosomes mediated transfer of lncRNA UCA1 results in increased tamoxifen resistance in breast cancer cells

lncRNA

In this study, researchers at the People’s Hospital of Shouguang compared the loading of urothelial carcinoma-associated 1 (UCA1) in exosomes between tamoxifen sensitive and tamoxifen resistant breast cancer cells and further investigated the role of exosomal transfer of UCA1 in the development of tamoxifen resistance in estrogen receptor (ER) positive breast cancer cells. The researchers isolated exosomes from the culture ...

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The long non-coding RNA 91H increases aggressive phenotype of breast cancer cells

Numerous genomic imprinting loci are regulated by long non-coding RNA (lncRNA). University of Lille researchers have previously identified a new lncRNA at the H19/IGF2 locus transcribed in H19 antisense orientation and named 91H. This RNA is conserved among mammals. In mice, 91H regulates positively IGF2 expression from a novel promoter. However, in human the function of 91H at the H19/IGF2 ...

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Dysregulation of long non-coding RNA in breast cancer

lncRNA

Long non-coding RNAs (lncRNAs), which occupy nearly 98% of genome, have crucial roles in cancer development, including breast cancer. Breast cancer is a disease with high incidence. Despite of recent progress in understanding the molecular mechanisms and combined therapy strategies, the functions and mechanisms of lncRNAs in breast cancer remains unclear. Researchers from Zhejiang University review the currently basic knowledge ...

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Affymetrix to Sponsor New Webinar Focusing on the Importance of Understanding lncRNAs in Breast Cancer Progression and Tumorigenesis

lncRNA

Breast cancer is the most commonly diagnosed cancer in women and is the second leading cause of cancer death among women. Hundreds of thousands of women worldwide lose their battle against this cancer each year, and it is estimated that one in eight US women will develop invasive breast cancer in her lifetime. The heterogeneity of breast cancer, with its ...

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LINC00520 plays a functional role in breast cancer

lncRNA

Long non-coding RNAs (lncRNAs) have been implicated in normal cellular homeostasis as well as pathophysiological conditions, including cancer. Harvard Medical School researchers performed global gene expression profiling of mammary epithelial cells transformed by oncogenic v-Src, and identified a large subset of uncharacterized lncRNAs potentially involved in breast cancer development. Specifically, their analysis revealed a novel lncRNA, LINC00520 that is upregulated ...

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Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer

Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, Indiana University researchers analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. They revealed two distinctive co-expression patterns associated with breast cancer, reflecting different underlying regulatory mechanisms: (1) ...

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Portraying breast cancers with long noncoding RNAs

lncRNA

Evidence is emerging that long noncoding RNAs (lncRNAs) may play a role in cancer development, but this role is not yet clear. Researchers from the ULB–Cancer Research Center performed a genome-wide transcriptional survey to explore the lncRNA landscape across 995 breast tissue samples. They identified 215 lncRNAs whose genes are aberrantly expressed in breast tumors, as compared to normal samples. ...

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