Tag Archives: BRCA1

A Long-noncoding RNA Regulates Repair of DNA Breaks in Triple-Negative Breast Cancer Cells

lncrna

LINP1 enhances the repair of DNA breaks by serving as a scaffold that links two other proteins in the repair machinery. Findings give “new insight” into biology of tough-to-treat breast cancer PHILADELPHIA – The discovery of long non-coding RNA (lncRNA) has dramatically changed the understanding of the biology of diseases such as cancer. The human genome contains about 20,000 protein-coding ...

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The role of lncRNA in maintaining genome stability

lncRNA

Long non-coding RNAs (lncRNAs) are important players in diverse biological processes. Upon DNA damage, cells activate a complex signaling cascade referred to as the DNA damage response (DDR). Using a microarray screen, researchers from the National Cancer Institute identify here a novel lncRNA, DDSR1 (DNA damage-sensitive RNA1), which is induced upon DNA damage. DDSR1 induction is triggered in an ATM-NF-κB pathway-dependent ...

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