Tag Archives: Braveheart

Long Noncoding RNAs in Pathological Cardiac Remodeling

lncRNA

DNA makes RNA, RNA makes protein, and protein makes us. This central dogma of life provides a simple description how an organism develops: DNA serves as a blueprint of the genetic information, and proteins are its functional and structural manifestation, whereas RNA mediates this process as a plotted construction plan. However, the relation between the genetic code and its biological ...

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G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage

lncRNA

Long non-coding RNAs (lncRNAs) are an emerging class of transcripts that can modulate gene expression; however, their mechanisms of action remain poorly understood. Here, MIT researchers experimentally determine the secondary structure of Braveheart (Bvht) using chemical probing methods and show that this ∼590 nt transcript has a modular fold. Using CRISPR/Cas9-mediated editing of mouse embryonic stem cells, they find that ...

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MIT biologists unravel lncRNA structure-to-function relationships

lncRNA

from MIT News by Anne Trafton – Several years ago, biologists discovered a new type of genetic material known as long noncoding RNA. This RNA does not code for proteins and is copied from sections of the genome once believed to be “junk DNA.” Since then, scientists have found evidence that long noncoding RNA, or lncRNA, plays roles in many ...

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MIT Team Shows How lncRNA Works

lncRNA

from Genetic Engineering News – Researchers at  MIT say they have deciphered the structure of one type of long noncoding RNA (lncRNA) and used that information to figure out how it interacts with a cellular protein to control the development of heart muscle cells. This is one of first studies to link the structure of lncRNAs to their function. “Emerging ...

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