Tag Archives: biogenesis

Unique features of long non-coding RNA biogenesis and function

lncRNA

The transcriptional landscape of all organisms is far more complex than was originally imagined, as the vast majority of genomic sequence is pervasively transcribed into a diverse range of protein-coding RNAs and non-coding RNAs (ncRNAs). In this expanded view of both the genome and the transcriptome, our catalogue of genetic elements is now brimming with long non-coding RNAs (lncRNAs), a ...

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A Feedforward Regulatory Loop involving Long Noncoding RNA Controls Early Phases of Myogenesis

The muscle-specific long noncoding RNA linc-MD1 was shown to be expressed during early phases of muscle differentiation and to trigger the switch to later stages by acting as a sponge for miR-133 and miR-135. Notably, linc-MD1 is also the host transcript of miR-133b, and their biogenesis is mutually exclusive. Here, researchers at Sapienza University of Rome describe that this alternative ...

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