Tag Archives: biogenesis

Unique features of long non-coding RNA biogenesis and function


The transcriptional landscape of all organisms is far more complex than was originally imagined, as the vast majority of genomic sequence is pervasively transcribed into a diverse range of protein-coding RNAs and non-coding RNAs (ncRNAs). In this expanded view of both the genome and the transcriptome, our catalogue of genetic elements is now brimming with long non-coding RNAs (lncRNAs), a ...

Read More »

A Feedforward Regulatory Loop involving Long Noncoding RNA Controls Early Phases of Myogenesis

The muscle-specific long noncoding RNA linc-MD1 was shown to be expressed during early phases of muscle differentiation and to trigger the switch to later stages by acting as a sponge for miR-133 and miR-135. Notably, linc-MD1 is also the host transcript of miR-133b, and their biogenesis is mutually exclusive. Here, researchers at Sapienza University of Rome describe that this alternative ...

Read More »