Tag Archives: autism

Genome’s ‘dark’ side steps into spotlight of autism research

lncRNA

from SpectrumNews by Nicholette Zeliadt – Given that genes make up a paltry 2 percent of the genome, they’ve received a disproportionate amount of attention from autism researchers. Slowly, however, the other 98 percent of the genome — the so-called ‘dark matter’ — is emerging from the shadows. Once considered nonfunctional or ‘junk DNA,’ these non-gene regions are now known ...

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Identification and prioritization of long non-coding RNAs associated with autism

Genetic studies have identified many risk loci for autism spectrum disorder (ASD) although causal factors in the majority of cases are still unknown. Currently, known ASD risk genes are all protein-coding genes; however, the vast majority of transcripts in humans are non-coding RNAs (ncRNAs) which do not encode proteins. Recently, long non-coding RNAs (lncRNAs) were shown to be highly expressed ...

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Of the RNAs expressed at different levels in the autism brains, 60 are long non-coding RNAs

exosome

from Spectrum News by Nicholette Zeliadt The brains of people with autism show a distinct molecular signature, according to the largest-yet postmortem study of people with the condition1. The signature reflects alterations in how genes are pieced together and expressed. The findings confirm and extend those from two smaller studies of autism brains — one from 2011 by the same ...

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Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

lncRNA

Autism spectrum disorder (ASD) involves substantial genetic contributions. These contributions are profoundly heterogeneous but may converge on common pathways that are not yet well understood. Here, through post-mortem genome-wide transcriptome analysis of the largest cohort of samples analysed so far, researchers from UCLA interrogate the noncoding transcriptome, alternative splicing, and upstream molecular regulators to broaden our understanding of molecular convergence ...

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No longer junk: Role of long noncoding RNAs in autism risk

lncRNA

by Nikolaos Mellios, Mriganka Sur RNA acts as the intermediary between genes and proteins, but the function of pieces of RNA that do not code for protein has, historically, been less clear. Researchers have ignored these noncoding RNAs until recently for not complying with the central dogma of biology — that a straight line runs from gene to RNA (transcription) ...

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Integrating the roles of long and small non-coding RNA in brain function and disease

lncRNA

Regulatory RNA is emerging as the major architect of cognitive evolution and innovation in the mammalian brain. While the protein machinery has remained largely constant throughout animal evolution, the non protein-coding transcriptome has expanded considerably to provide essential and widespread cellular regulation, partly through directing generic protein function. Both long (long non-coding RNA) and small non-coding RNAs (for example, microRNA) ...

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