Tag Archives: atlas venture

AR promotes RCC via lncRNA interaction


The androgen receptor (AR) regulates progression of renal cell carcinoma (RCC) via a mechanism dependent on VHL status and hypoxia, according to data published in Oncogene. RCC is associated with inactivation of the von Hippel–Lindau (VHL) suppressor protein, which targets hypoxia-inducible factors HIF-1α and HIF-2α. VHL inactivation is associated with a good prognosis, but the mechanisms of this effect are ...

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