Tag Archives: antisense RNA

High-throughput analysis of conservation and functional composition of the still-mysterious lncRNA genes

Recent advances in genome wide studies have revealed the abundance of long non-coding RNAs (lncRNAs) in mammalian transcriptomes. The ENCODE Consortium has elucidated the prevalence of human lncRNA genes, which are as numerous as protein-coding genes. Surprisingly, many lncRNAs do not show the same pattern of high interspecies conservation as protein-coding genes. The absence of functional studies and the frequent ...

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Featured long non-coding RNA – PTENpg1


PTEN is a tumor-suppressor gene that has been shown to be under the regulatory control of a PTEN pseudogene expressed noncoding RNA, PTENpg1. Here, researchers at the Karolinska Institutet, Sweden characterize a previously unidentified PTENpg1-encoded antisense RNA (asRNA), which regulates PTEN transcription and PTEN mRNA stability. They found two PTENpg1 asRNA isoforms, α and β. The α isoform functions in trans, ...

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Silencing by the imprinted Airn macro lncRNA


The majority of the mammalian genome is transcribed into long non-coding (lnc) RNAs, transcripts longer than 200 nucleotides and devoid of protein-coding potential. Recent genome-wide mapping efforts led to the identification of thousands novel lncRNAs, but so far only few have been functionally analyzed. Fifteen years ago, our group discovered Airn (antisense to Igf2r RNA non-coding), the first autosomal lncRNA ...

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Featured long non-coding RNA – Dlx1as


Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer. This emerging importance of lncRNAs, along with recent reports of a functional lncRNA encoded by the mouse Dlx5-Dlx6 locus, led researchers at the ...

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