Tag Archives: androgen receptor

Prostate cancer-associated lncRNAs

lncRNA

Long non-coding RNA (LncRNA) is defined as an RNA transcript that does not encode any protein, with a length longer than 200 nt. Based on the recent advances in high-throughput sequencing techniques, a large number of lncRNAs have been characterized as functional transcripts that play important roles in various biological processes as well as pathologic states. In a research field of ...

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Androgen-responsive lncRNAs are diagnostic and prognostic markers for prostate cancer

lncRNA

Prostate cancer (PCa) is a leading cause of mortality among males. Long non-coding RNAs (lncRNAs) are subclass of noncoding RNAs that may act as biomarkers and therapeutic targets. In this study, researchers at Fudan University firstly conducted analysis of global lncRNA expression patterns by using their own cohort (GSE73397) and two public available gene expression datasets: The Cancer Genome Atlas ...

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AR promotes RCC via lncRNA interaction

lncRNA

The androgen receptor (AR) regulates progression of renal cell carcinoma (RCC) via a mechanism dependent on VHL status and hypoxia, according to data published in Oncogene. RCC is associated with inactivation of the von Hippel–Lindau (VHL) suppressor protein, which targets hypoxia-inducible factors HIF-1α and HIF-2α. VHL inactivation is associated with a good prognosis, but the mechanisms of this effect are ...

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Long noncoding RNAs and prostate carcinogenesis: the missing 'linc'?

Long noncoding RNAs (lncRNAs) are rapidly becoming essential pieces in the cancer puzzle. Our understanding of their functional capabilities is in its infancy. One certain fact, however, is that their molecular interactions extend beyond chromatin complexes into diverse biological processes. In prostate cancer, aberrant expression of lncRNAs is associated with disease progression. Overexpression of oncogenic lncRNAs promotes tumor-cell proliferation and ...

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