Tag Archives: Alzheimer’s Disease

DES-ncRNA – A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining

lncRNA

Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding ...

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In Alzheimer’s Disease the majority of lncRNA genes may be transcriptionally regulated by histone modification

lncRNA

Increasing studies have revealed that long noncoding RNAs (lncRNAs) are not transcriptional noise but play important roles in the regulation of a wide range of biological processes, and the dysregulation of lncRNA genes is associated with disease development. Alzheimer’s disease (AD) is a chronic neurodegenerative disease that usually starts slowly and gets worse over time. However, little is known about ...

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Alzheimer’s Disease Model Displays Distinct Hippocampal Expression Profiles of Long Non-coding RNAs

lncRNA

Alzheimer’s disease (AD), the most prevalent form of dementia worldwide, is a complex neurodegenerative disease characterized by the progressive loss of memory and other cognitive functions. The pathogenesis of AD is not yet completely understood. Although long non-coding RNAs (lncRNAs) have recently been shown to play a role in AD pathogenesis, the specific influences of lncRNAs in AD remain largely ...

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A Network Based Method for Analysis of lncRNA-Disease Associations and Prediction of lncRNAs Implicated in Diseases

Increasing evidence has indicated that long non-coding RNAs (lncRNAs) are implicated in and associated with many complex human diseases. Despite of the accumulation of lncRNA-disease associations, only a few studies had studied the roles of these associations in pathogenesis. In this paper, researchers at Xidian University investigated lncRNA-disease associations from a network view to understand the contribution of these lncRNAs ...

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A Network Based Method for Analysis of lncRNA-Disease Associations and Prediction of lncRNAs Implicated in Diseases

Increasing evidence has indicated that long non-coding RNAs (lncRNAs) are implicated in and associated with many complex human diseases. Despite of the accumulation of lncRNA-disease associations, only a few studies had studied the roles of these associations in pathogenesis. In this paper, researchers at Xidian University investigated lncRNA-disease associations from a network view to understand the contribution of these lncRNAs ...

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A Network Based Method for Analysis of lncRNA-Disease Associations and Prediction of lncRNAs Implicated in Diseases

Increasing evidence has indicated that long non-coding RNAs (lncRNAs) are implicated in and associated with many complex human diseases. Despite of the accumulation of lncRNA-disease associations, only a few studies had studied the roles of these associations in pathogenesis. In this paper, researchers from the Xidian University, China investigated lncRNA-disease associations from a network view to understand the contribution of ...

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Scientists at Genome Institute of Singapore Discover Gene that Controls the Birth of Neurons

By ACN Newswire – August 27, 2013 10:36 PM EDT Discovery of long non-coding RNA’s role in neurogenesis may lead to cures for diseases such as Alzheimer’s disease Singapore, Aug 28, 2013 – (ACN Newswire) – Scientists at A*STAR’s Genome Institute of Singapore (GIS) have discovered an unusual gene that controls the generation of neurons[1]. This important finding, which is ...

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Non-coding RNAs in Alzheimer's disease

lncRNA

Alzheimer’s disease (AD) is a complex neurodegenerative disorder and the most common dementia among the elderly. Accumulating research indicates that noncoding RNAs (ncRNAs), especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are increasingly being implicated in AD. MiRNAs are conserved small ncRNAs that control gene expression post-transcriptionally while lncRNAs function in many ways. Recent profiling research in human or mouse ...

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Exploratory Bioinformatics Study of lncRNAs in Alzheimer’s Disease mRNA Sequences with Application to Drug Development

Long noncoding RNA (lncRNA) within mRNA sequences of Alzheimer’s disease genes, namely, APP, APOE, PSEN1, and PSEN2, has been analyzed using fractal dimension (FD) computation and correlation analysis.  A team led by researchers from CUNY Queensborough examined lncRNA by comparing mRNA FD to corresponding coding DNA sequences (CDSs) FD.  APP, APOE, and PSEN1 CDSs select slightly higher FDs compared to ...

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