Tag Archives: algorithm

ASSA – Transcriptome-Wide Prediction Of lncRNA-RNA Interactions By Thermodynamics

lncRNA

The discovery of thousands of long noncoding RNAs (lncRNAs) in mammals raises a question about their functionality. It has been shown that some of them function post-transcriptionally via formation of inter-molecular duplexes. Sequence alignment tools are frequently used for transcriptome-wide prediction of RNA-RNA interactions. However, such approaches have poor prediction accuracy since they ignore RNA secondary structure and interaction energy. ...

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LncPriCNet – Global Prioritizing Disease Candidate lncRNAs via a Multi-level Composite Network

lncRNA

LncRNAs play pivotal roles in many important biological processes, but research on the functions of lncRNAs in human disease is still in its infancy. Therefore, it is urgent to prioritize lncRNAs that are potentially associated with diseases. Researchers from the Shanghai Jiao Tong University have developed a novel algorithm, LncPriCNet, that uses a multi-level composite network to prioritize candidate lncRNAs ...

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