Tag Archives: acute myeloid leukemia

Researchers develop new approach to study long non-coding RNAs

lncrna

New method identifies and determines role for newly discovered genetic units Until recently, scientific research concentrated almost exclusively on the 2 percent of the genome’s protein coding regions, virtually ignoring the other 98 percent – a vast universe of non-coding genetic material previously dismissed as ‘junk.’ In the past 10 years, scientists have discovered thousands of new long non-coding RNAs ...

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Long noncoding RNA expression profile in acute myeloid leukemia identifies a distinct signature and a new biomarker

lncRNA

Long noncoding RNAs are defined as transcripts larger than 200 nucleotides but without protein-coding potential. Cumulative evidence points towards an important role of long noncoding RNAs in cancer initiation, development and progression. In this study researchers from the Cancer Research Center of Toulouse sought to evaluate the long noncoding RNA expression profile of patients with cytogenetically normal acute myeloid leukemia. ...

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lncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia

lncrna

Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy with great variability of prognostic behaviors. Previous studies have reported that long non-coding RNAs (lncRNAs) play an important role in AML and may thus be used as potential prognostic biomarkers. However, thus use of lncRNAs as prognostic biomarkers in AML and their detailed mechanisms of action in this disease have ...

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Long noncoding RNAs – A Novel Prognostic Marker In AML

lncRNA

From Drug Discovery News A new study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) describes a novel marker that might help doctors choose the least toxic, most effective treatment for many older patients with acute myeloid leukemia (AML). AML occurs mainly ...

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