A study from Washington University School of Medicine in St. Louis has identified an long non-coding RNA molecule that suppresses prostate tumors...
Read More »Search Results for: prostate cancer
UVA Discovers lncRNA that regulates gene controlling growth of prostate cancer
Researchers have discovered a long non-coding RNA which could be used as a biomarker and in new therapies for prostate cancer. Cancer researchers at the School of Medicine have identified a key to controlling the growth and progression of prostate cancer, the second most common cancer in men. The researchers have dubbed this key “HULLK,” and they believe it could be used ...
Read More »The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications
To date, a comprehensive characterization of the dynamic landscape of lncRNAs during the neuroendocrine transdifferentiation (NEtD) process has not been performed. A temporal analysis of the...
Read More »Tumor-derived exosomal long noncoding RNAs as promising diagnostic biomarkers for prostate cancer
Exosomal circulating long non-coding RNAs (lncRNAs) in blood are emerging as clinically useful and non-invasive biomarkers for tumor diagnosis. However, normal cells can also secrete exosomes, so it...
Read More »Prostate cancer-associated lncRNAs
Long non-coding RNA (LncRNA) is defined as an RNA transcript that does not encode any protein, with a length longer than 200 nt. Based on the recent advances in high-throughput sequencing techniques, a large number of lncRNAs have been characterized as functional transcripts that play important roles in various biological processes as well as pathologic states. In a research field of ...
Read More »The prognostic value of long noncoding RNAs in prostate cancer
The abnormally expressed LncRNAs played irreplaceable roles in the prognosis of prostate cancer (PCa). Therefore, researchers from Wuhan University conducted this systematic review and meta-analysis to summarize the association between the expression of LncRNAs, prognosis and clinicopathology of PCa. 18 eligible studies were recruited into their analysis, including 18 on prognosis and 9 on clinicopathological features. Results indicated that aberrant ...
Read More »A panel of four-long noncoding RNA signatures predicts prostate cancer survival
Growing evidences showed that lncRNAs abnormally expressed in cancer tissues and played irreplaceable roles in tumorigenesis, progression and metastasis. In present study, researchers from Yangzhou University aimed to identify lncRNA expression signature that can predict biochemical recurrence-free (BCR-free) survival of prostate cancer (PCa) patients. A total of 291 patients with pathologic confirmed PCa in The Cancer Genome Atlas dataset were ...
Read More »LncRNAs and miRNAs – potential biomarkers and therapeutic targets for prostate cancer
Prostate cancer (PCa) is the second lethal disease for men in western countries. Although androgen receptor (AR) signaling has been widely investigated, noncoding RNAs (ncRNAs), deficient of open reading frame, have also received considerable attention. Growing studies showed that the aberrant ncRNAs expression contributed to cell proliferation, metastasis and drug resistance in PCa. Therefore, therapeutically targeting ncRNAs may synergize androgen ...
Read More »MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Prostate Cancer Cells
In the complex network of nuclear hormone receptors, the long non-coding RNAs (lncRNAs) are emerging as critical determinants of hormone action. Here researchers from the Institute of Cell Biology and Neurobiology, Rome investigated the involvement of selected cancer-associated lncRNAs in Estrogen Receptor (ER) signaling. Prior studies by Chromatin Immunoprecipitation (ChIP) Sequencing showed that in prostate cancer cells ERs form a ...
Read More »Risk-associated SNPs promote prostate cancer through modulating lncRNA expression
Long noncoding RNAs (lncRNAs) represent an attractive class of candidates to mediate cancer risk. Through integrative analysis of the lncRNA transcriptome with genomic data and SNP data from prostate cancer genome-wide association studies (GWAS), researchers at the Princess Margaret Cancer Center identified 45 candidate lncRNAs associated with risk to prostate cancer. They further evaluated the mechanism underlying the top hit, ...
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