Role of Long non-coding RNAs in Epigenetic Regulation


The main function of lncRNA in regulation is to control expression of defined genes. For their role in development, they modulate chromatin structure recruiting epigenetic modification proteins to defined sites of the genome. Examples of this function are HOTAIR, Xist and Kcnqot1. HOTAIR is involved in limb formation and cancer meanwhile Kcnqot1 is involved with the imprinting of its loci.

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