Regional Epigenetic Down- and Up-Regulation in Cancer & lncRNAs with Potential Functionality


The focus of this GEN Market & Tech Analysis report is to present a snapshot of regional epigenetic down- and up-regulation in cancer with a focus toward prostate cancer.

We present here long-range epigenetic silencing (LRES) as a means for downregulation of stretches of the genome as well as long-range epigenetic activation (LREA). These two opposing effects appear to be mediated by an interplay between DNA methylation and chromatin modification. We’ve focused this analysis on an interrogation of prostate cancer.

Also presented herein are potential associations of long noncoding RNAs (lncRNAs) with distinct cancer classes. The potential utility of lncRNAs in finely modulating the expression of distinct regions of the genome makes this class of molecules attractive potential biomarkers and perhaps even therapeutic targets in the future.

Leave a Reply

Your email address will not be published. Required fields are marked *