Postdoc Position Available – Myc regulated lncRNAs in B-cell lymphoma


Department Department of Pathology & Medical Biology
Work location Groningen
Apply no later than 14 September 2014

lncRNAWorking environment

Project description
Our lab is interested in understanding the function of non-coding RNAs in B-cell lymphoma. Besides studying microRNAs for over ten years, we more recently gained interest in the function of long non-coding RNAs in B cell lymphoma. Long non-coding RNAs are an exciting group of transcripts involved in many cell physiological processes, and deregulation of them has been associated with many diseases such as cancer. One of the important oncogenes in B-cell lymphoma is the transcription factor Myc that is known to regulate expression of a large number of genes that are important for malignant transformation. Using a comprehensive gene expression analysis approach, we recently identified a group of Myc-regulated long non-coding RNAs. The objective of this project funded by the pediatric oncology foundation Groningen (SKOG) is to determine to what extend these long non-coding RNAs are involved in the pathogenesis of Myc-associated B-cell lymphoma and to unveil the underlying mechanisms.

Our Research group is located at the Department of Pathology & Medical Biology and we have close collaborations with the Departments of Genetics and Hematology. The research line is embedded within the Cancer Research Center Groningen. The focus of this research center is to initiate and stimulate the translation of fundamental insights from preclinical research programs on oncogenesis and tumor behavior into cancer prevention, improvement of early detection of cancer and better treatment for cancer patients. The non-coding B cell lymphoma group is part of the Stem cells Aging, Leukemia and Lymphoma (SALL) subprogram which includes various research groups of the Hematology, Stem cell biology, Pediatric oncology and Pathology. Besides an excellent international scientific environment we have state-of-the-art research facilities including those needed for NGS, imaging, qRT-PCR, array analysis and many others.

What do we need

  • PhD in molecular biology, cancer research or equivalent.
  • You are an outstanding enthusiastic scientist who is pro-active, independent and motivated to setup assays to mechanistically study lncRNAs.
  • You are a team player and aim to pursue a career in scientific research.
  • You have experience with diverse molecular biology techniques and bioinformatics analysis is a strong advantage.
  • You have excellent English skills, both oral and written.
  • Experience in writing scientific papers and presentation of your work at scientific meetings.
  • Experience in supervision of students and technicians.
  • Fascination for non-coding RNA is an advantage.

The UMCG has a preventive Hepatitis B policy. You may be required to build up sufficient protection against Hepatitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.

What do we offer

  • A postdoc position according to conditions of employment that comply with the Collective Labor Agreement for Medical Centers (CAO-UMC).
  • A contract for one year with a second year extension after positive evaluation.
  • Based on qualifications and experience a maximum salary of € 4.070,- gross a month (scale 10) for a fulltime position.

More information
For more information about this vacancy you may contact:
Mr. Dr. J. Kluiver, molecular biologist, phone: +31 50 3615788, email: (please do not use for applications).
Ms. Prof. dr. A. van den Berg, molecular biologist, phone: +31 50 3611476, email: (please do not use for applications).

Applying for a job

Please use the the digital application form at the bottom of this page – only these will be processed.
You can apply until 14 September 2014.
Immediately after sending the digital application form you will receive an email- confirmation with further information.
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