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A 2-year postdoctoral position is available in the Inserm Unit “Nutrition, Metabolisms and Cancer” (NuMeCan) located in Rennes, France. The successful applicant will join the team “TGF-beta and cancer” interested in elucidating the molecular mechanisms underlying the functional duality of TGF-beta in liver cancer (https://numecan.univ-rennes1.fr/?page_id=782&lang=en). The team gathers basic researchers and clinicians with a common interest and complementary expertise in liver cancer.
Research topic: Functional characterization of TGF-beta-regulated non-coding RNA (ncRNA) in liver cancer (specific Funds from the French Plan-Cancer / National Cancer Institute-Inserm).
Background: Transforming Growth Factor beta (TGFb) plays a key role in liver carcinogenesis and interfering with this pathway has been proposed as an emerging relevant therapeutic strategy. However, this pathway is complex given that TGFb exhibits tumor suppressive or promoting properties, depending on the tumor stage. The molecular mechanisms involved in this functional duality are not fully understood. The project specifically aims at characterizing ncRNA (long and circular) as novel effectors and regulators of the TGFb pathway in liver cancer. A better characterization of the molecular mechanisms involved in the functional duality of TGFb will provide a rationale for efficient targeted therapies and innovative biomarkers.
Candidate: We are looking for a highly motivated, creative and rigorous candidate with a strong interest and a publication supported experience in cancer and ncRNA biology. Working experience in molecular and cellular biology is a pre-requisite. Competences in genomics and bioinformatics will be an advantage. Recruitment: end 2018-early 2019.
Application: Please send your complete application documents (i.e. a CV with a description of your research experience and technical skills, publication record, motivation letter, two references) in a single pdf file to cedric.coulouarn@inserm.fr
