Search Results for: prostate cancer

A Method for Detecting Long Non-Coding RNAs with Tiled RNA Expression Microarrays

Long non-coding ribonucleic acids (lncRNAs) have been proposed as biomarkers in prostate cancer. This paper proposes a selection method which uses data from tiled microarrays to identify relatively long regions of moderate expression independent of the microarray platform and probe design. The method is used to search for candidate long non-coding ribonucleic acids (lncRNAs) at locus 8q24 and is run ...

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Featured long non-coding RNA – PCAT-1

lncRNA

Impairment of double-stranded DNA break (DSB) repair is essential to many cancers. However, although mutations in DSB repair proteins are common in hereditary cancers, mechanisms of impaired DSB repair in sporadic cancers remain incompletely understood. Here, a team led by researchers at the Michigan Center for Translational Pathology describes the first role for a long noncoding RNA (lncRNA) in DSB ...

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Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target

lncRNA

Metastatic prostate cancer (PCa) is still an incurable disease. Long non-coding RNAs (lncRNAs) may be an overlooked source of cancer biomarkers and therapeutic targets. Researchers at the BC Cancer Agency Cancer Research Centre, Canada performed RNA sequencing on paired metastatic/non-metastatic PCa xenografts derived from clinical specimens. The most highly up-regulated transcript was LOC728606, a lncRNA now designated PCAT18. PCAT18 is ...

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lncRNAs and Epigenetic Modulations: Potential Hotspots

lncRNA

from Genetic Engineering News Market and Technology Analysis The focus of this GEN Market & Tech Analysis report is to present a snapshot of regional epigenetic down- and up-regulation in cancer with a focus toward prostate cancer. We present here long-range epigenetic silencing (LRES) as a means for downregulation of stretches of the genome as well as long-range epigenetic activation ...

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What are lncRNAs?

lncRNA

from Exiqon.com It was traditionally thought that the transcriptome would be mostly comprised of mRNAs, however advances in high-throughput RNA sequencing technologies have revealed the complexity of our genome. Non-coding RNA is now known to make up the majority of transcribed RNAs and in addition to those that carry out well-known housekeeping functions (e.g. tRNA, rRNA etc), many different types ...

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RNA: The genome's rising stars

RNA

from Nature by Amy Maxmen When Saba Valadkhan lingered in the hallways at conferences, absorbed in discussions about the strands of ‘junk’ DNA that litter the human genome, she was not looking for work. She was consumed with curiosity about the possibility that long RNA sequences that do not encode proteins nevertheless have a function — enhancing or suppressing gene ...

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Featured long non-coding RNA – PCGEM1

Prostate cancer (PCa) gene expression marker 1 (PCGEM1), a long noncoding RNA, has drawn increasing attention for its important role in PCa. However, the association between genetic variations in the PCGEM1 gene and risk of PCa has not been investigated yet. Researchers at Nanjing Medical University, China investigated the effect of two tagging single-nucleotide polymorphism (tSNPs; rs6434568 and rs16834898) in ...

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LncRNAs2Pathways – Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method

Long non-coding RNAs (lncRNAs) have been demonstrated to play essential roles in diverse cellular processes and biological functions. Exploring the functions associated with lncRNAs may help provide insight into their underlying biological mechanisms. The current methods primarily focus on investigating the functions of individual lncRNAs; however, essential biological functions may be affected by the combinatorial effects of multiple lncRNAs. Here, ...

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Post-doc Position Available – Non-coding RNAs

lncRNA

Job Description A postdoctoral Associate position is available to study the role of non-coding RNAs (long noncoding RNA and microRNAs) in cancer (prostate and melanoma) metabolism in our laboratory at Sanford-Burnham Medical Discovery Institute, Orlando FL USA.  Several putative oncogenic and tumor suppressor non-coding RNAs have been identified (Mazar et al Mol. Cell. Biol 2016, Wei et al., JID 2016) in our ...

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Featured New Product – The SmartChip Human LncRNA1 Panel

The field of lncRNA research is in the midst of a rapid discovery phase, but that doesn’t mean your reagents have to be“experimental”. In collaboration with Biogazelle, we’ve designed SmartChip Human lncRNA-1 Panels to maximize your investigation of lncRNA expression. They contain over 1700 triplicate, predispensed PCR assays that have been extensively validated and annotated. In addition, we’ve ensured that ...

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