Search Results for: prostate cancer

Regulatory roles played by long intergenic noncoding RNA in three types of cancer

from Biology Computes Ying Sha, Sanjeev Sariya, Ali M Pirani, Adrian Lawsin BACKGROUND Cancer is a disease of aberrant gene expression.  Genome-wide association studies in cancer reveal that more than 80% of cancer-associated SNPs (single-nucleotide polymorphism) occur in noncoding regions of the genome.  Long noncoding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides.  This arbitrary limit distinguishes lncRNAs from miRNAs (microRNA), piRNAs (piwi-interacting ...

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Regional Epigenetic Down- and Up-Regulation in Cancer & lncRNAs with Potential Functionality

The focus of this GEN Market & Tech Analysis report is to present a snapshot of regional epigenetic down- and up-regulation in cancer with a focus toward prostate cancer. We present here long-range epigenetic silencing (LRES) as a means for downregulation of stretches of the genome as well as long-range epigenetic activation (LREA). These two opposing effects appear to be ...

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Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer

lncRNA

Despite growing appreciation of the importance of long noncoding RNAs (lncRNAs) in normal physiology and disease, our knowledge of cancer-related lncRNAs remains limited. By repurposing microarray probes, researchers at Tongji University, China constructed expression profiles of 10,207 lncRNA genes in approximately 1,300 tumors over four different cancer types. Through integrative analysis of the lncRNA expression profiles with clinical outcome and ...

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Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer

Long noncoding RNAs (lncRNA) are emerging as key molecules in human cancer. Prostate cancer–associated ncRNA transcripts 1 (PCAT-1), a lncRNA, has been recently revealed involving in human prostate cancer progression. However, whether PCAT-1 could serve as novel biomarker to predict prognosis in colorectal cancer (CRC) or not is unknown. In this study researchers from Sun Yat-Sen University, China explored the ...

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The Future of Biomarkers and Genomics

lncrna

from UroToday.com by  Zachary Klaassen, – Professor Manfred Wirth from Germany provided an update on the future of biomarkers and genomics at this afternoon’s EAU Update in Prostate Cancer in Vienna, Austria. Dr. Wirth divided his presentation into three subsections: Why are biomarkers needed for prostate cancer? There are several reasons according to Dr. Wirth why biomarkers are needed for prostate cancer, ...

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The Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks

lncRNA

DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effects of these ...

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Chemicals from the diet can influence the expression of functionally important lncRNAs

lncrna

Long noncoding RNAs (lncRNAs) have emerged as important in cancer development and progression. The impact of diet on lncRNA expression is largely unknown. Sulforaphane (SFN), obtained from vegetables like broccoli, can prevent and suppress cancer formation. Here researchers at Oregon State University tested the hypothesis that SFN attenuates the expression of cancer-associated lncRNAs. They analyzed whole-genome RNA-sequencing data of normal ...

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Upcoming Webinar – RNA-ISH for Long non-coding RNAs – new game changers in pathology

lncRNA

August 11, 2016   –   11:00AM PST, 2:00PM ET, 7:00PM GMT Rohit Mehra, M.D. Assistant Professor of Pathology Member-Michigan Center for Translational Pathology MLabs Genitourinary Service Line Director Co-Director, University of Michigan Rapid Autopsy Discovery Program The central dogma that forms the backbone of molecular biology is that DNA codes for RNA (transcription) which then codes for proteins (translation). However, studies ...

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Long noncoding RNA networks of suppression

lncRNA

Of the approximately 10,000 long noncoding (lnc) RNAs encoded in the human genome, the functions of only a few have been characterized. Mounting evidence suggests that long noncoding RNAs (lncRNAs) can function as microRNA sponges and compete for microRNA binding to protein-coding transcripts. However, the prevalence, functional significance and targets of lncRNA-mediated sponge regulation of cancer are mostly unknown. Here, ...

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Featured lncRNA – PCAT5

lncRNA

Castration-resistant prostate cancer (CRPC) that arise after the failure of androgen blocking therapies cause most of the deaths from prostate cancer (PC), intensifying the need to fully understand CRPC pathophysiology. A team led by researchers at MD Anderson Cancer Center characterized the transcriptomic differences between untreated PC and locally recurrent CRPC and they report the identification of 145 previously unannotated ...

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