Search Results for: prostate cancer

Dietary anti-cancer compound may work by influence over lncRNAs

lncRNA

Researchers have discovered one of the reasons why broccoli may be good for your health.  They found that sulforaphane, a dietary compound from broccoli that’s known to help prevent prostate cancer, may work through its influence on long, non-coding RNAs. This is another step forward in a compelling new area of study on the underlying genetics of cancer development and ...

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Potential of Long Non-coding RNAs in Cancer Patients: From Bio-markers to Therapeutic Targets

lncRNA

Because of high specificity and easy detection in the tissues, serum, plasma, urine and saliva, interest in exploring the potential of long non-coding RNAs (lncRNAs) in cancer patients continues to increase. LncRNAs have shown potential as a bio-marker in the diagnosis and prognosis of bladder cancer, prostate cancer, gastric cancer, pancreatic cancer, breast cancer, and many other cancer types. Some ...

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CSHL scientists test an antisense method of targeting long noncoding RNAs overexpressed in breast cancers

lncRNAs

The human body produces 100,000 or more different proteins. Yet, amazingly, only two percent of the human genome actually encodes proteins. Nearly 80 percent of the rest of the genome is transcribed into RNA that does not code for proteins. Two big questions facing scientists are: How much of this “non-coding” RNA is actually functional? And does it play a ...

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University of Hawaii Cancer Center researchers use “big data” for lncRNA discoveries

HONOLULU – University of Hawai’i Cancer Center researchers used “Big Data” to discover potential cancer biomarkers, a panel of six long intergenic non-coding RNAs (lincRNAs), for the diagnosis of all types of cancers including lung, breast, prostate, liver and ovarian cancers. “These biomarkers are highly accurate and robust, up to 97 percent, and could be developed into an early screening ...

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An Evolutionary Relic of the Genome Causes Cancer

BOSTON — Pseudogenes, a sub-class of long non-coding RNA (lncRNA) that developed from the genome’s 20,000 protein-coding genes but lost the ability to produce proteins, have long been considered nothing more than genomic “junk.” Yet the retention of these 20,000 mysterious remnants during evolution has suggested that they may in fact possess biological functions and contribute to the development of ...

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Researchers open ‘Pandora’s box’ of potential cancer biomarkers

lncRNA

Analysis describes global landscape of relatively unexplored part of human genome University of Michigan Health System ANN ARBOR, Mich. — A new analysis opens the door to discovery of thousands of potential new cancer biomarkers. Researchers at the University of Michigan Comprehensive Cancer Center analyzed the global landscape of a portion of the genome that has not been previously well-explored ...

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Long noncoding RNAs and prostate carcinogenesis: the missing 'linc'?

Long noncoding RNAs (lncRNAs) are rapidly becoming essential pieces in the cancer puzzle. Our understanding of their functional capabilities is in its infancy. One certain fact, however, is that their molecular interactions extend beyond chromatin complexes into diverse biological processes. In prostate cancer, aberrant expression of lncRNAs is associated with disease progression. Overexpression of oncogenic lncRNAs promotes tumor-cell proliferation and ...

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Salk Institute study identifies novel regulator of key gene expression in cancer

Findings may lead to new targets for cancer treatment LA JOLLA, CA—Scientists at the Salk Institute for Biological Studies have identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code ...

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Salk Institute study identifies novel regulator of key gene expression in cancer

Findings may lead to new targets for cancer treatment LA JOLLA, CA—Scientists at the Salk Institute for Biological Studies have identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code ...

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Long Noncoding RNA: “LNCs” to Cancer

lncRNA

In recent years we have witnessed a paradigm shift concerning the long-lasting controversy over “junk DNA” in the human genome. It is now well established that, besides the roughly 25 000 protein-coding genes, the genome contains tens of thousands of functional elements. In addition, the completion of the ENCODE project—the functional annotation of all regulatory regions of the human genome—has ...

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