Search Results for: prostate cancer

Non-coding RNAs in Prostate Cancer: the Long and the Short of it

lncRNA

As the leading culprit in cancer incidence for American men, prostate cancer continues to pose significant diagnostic, prognostic and therapeutic tribulations for clinicians. The vast spectrum of disease behavior warrants better molecular classification to facilitate the development of more robust biomarkers that can identify the more aggressive and clinically significant tumor subtypes that require treatment. The untranslated portion of the ...

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Targeting aggressive prostate cancer

Collaborative study shows how non-coding RNAs fuel cancer growth (SACRAMENTO, Calif.) — A team of researchers from UC Davis, UC San Diego and other institutions has identified a key mechanism behind aggressive prostate cancer. Published on August 14, 2013 in Nature, the study shows that two long non-coding RNAs (PRNCR1 and PCGEM1) activate androgen receptors, circumventing androgen-deprivation therapy. In their active state, ...

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Long noncoding RNAs: new players in prostate cancer

lncRNA

Prostate cancer is the most common type of cancer and frequent cause of cancer-related mortality in men worldwide. Despite its commonness, the underlying molecular mechanism of prostate cancer is not completely understood. Long noncoding RNAs (lncRNAs) are being implicated in the complex network of an apparent cancer initiatome and hundreds of lncRNAs are differentially expressed in various types of cancer ...

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Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer.

lncRNA

Examining plasma RNA is an emerging non-invasive diagnosis technique. However, whether tumour-derived long non-coding RNAs (lncRNAs) in plasma can be used as a novel approach to detect human prostate cancer (PCa) has not yet been established. The study was divided into three parts: (1) the characteristics of PCa-related lncRNA fragments were systematically studied in the plasma or serum of 25 ...

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Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines

While the role of small non-coding RNAs, such as miRNAs, in apoptosis control is well established, long non-coding RNAs (lncRNAs) have received less attention. Growth Arrest-Specific 5 (GAS5) encodes multiple snoRNAs within its introns, whilst exonic sequences produce lncRNA which can act as a riborepressor of the glucocorticoid and related receptors. GAS5 negatively regulates the survival of lymphoid and breast ...

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RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings

lncRNA

There are remarkable disparities among patients of different races with prostate cancer; however, the mechanism underlying this difference remains unclear. Here, a team led by researchers at the Second Military Medical University, China present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese population using RNA-seq, revealing tremendous diversity ...

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Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer

High-throughput techniques have identified numerous antisense (AS) transcripts and long non-coding RNAs (ncRNAs). However, their significance in cancer biology remains largely unknown. Here, researchers at the University of Tokyo, Japan report an androgen-responsive long ncRNA, CTBP1-AS, located in the AS region of C-terminal binding protein 1 (CTBP1), which is a corepressor for androgen receptor. CTBP1-AS is predominantly localized in the ...

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Long Non-Coding RNAs and Prostate Cancer

A new class of transcripts, long non-coding RNAs (lncRNAs), has been recently found to be pervasively transcribed in the genome. These mRNA-like molecules, which lack significant protein-coding capacity, once thought to be a part of the dark matter, now have been implicated in a wide range of biological functions through diverse and as yet poorly understood molecular mechanisms. Multiple facets ...

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Long Noncoding RNA in Prostate, Bladder, and Kidney Cancer

lncRNA

LncRNAs are important regulators of gene expression interacting with the major pathways of cell growth, proliferation, differentiation, and survival. Alterations in the function of lncRNAs promote tumour formation, progression, and metastasis of prostate, bladder, and kidney cancer. LncRNAs can be used as noninvasive tumour markers in urologic malignancies. Increased knowledge of the molecular mechanisms by which lncRNAs perform their function ...

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Researchers hypothesize that the prostate-specific lncRNA PCA3 has been introduced into the human genome by an ancient virus

Prostate cancer, the most frequent type of cancer in men, is surpassed only by lung cancer in causing cancer-related death. Despite major progress in defining the mutational landscape of this tumor, its etiology remains obscure. The intronic long-noncoding RNA (lncRNA) PCA3 is a specific marker of prostate cancer that acts as a trans-dominant negative oncogene to down-regulate the tumor suppressor ...

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